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• W1971097984 abstract "In this study we describe a new angiotensin antagonist [Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, (A-779)] selective for the heptapeptide angiotensin-(1–7) [Ang-(1–7)]. A-779 blocked the antidiuretic effect of Ang-(1–7) in water-loaded rats and the changes in blood pressure produced by Ang-(1–7) microinjection into the dorsal-medial and ventrolateral medulla. In contrast, A-779 did not change the dipsogenic, pressor, or myotropic effects of angiotensin II (Ang II). Also, A-779 did not affect the antidiuretic effect of vasopressin or the contractile effects of angiotensin III, bradykinin, or substance P on the rat ileum. In the rostral ventrolateral medulla, the pressor effect produced by Ang-(1–7) microinjection was completely blocked by A-779 but not by AT1 or AT2 receptor antagonists (DUP 753 and CGP 42112A, respectively). Conversely, the pressor effect produced by Ang II was not changed by A-779 but was completely blocked by DUP 753. Binding studies substantiated these observations: A-779 did not compete significantly for 125I-Ang II binding to adrenocortical membranes at up to a 1 μM concentration. Low affinity binding was also observed in adrenomedullary membranes with an IC50 greater than 10 μM. Our results show that A-779 is a potent and selective antagonist for Ang-(1–7). More importantly, our data indicate that specific angiotensin receptors mediate the central and peripheral actions of Ang-(1–7)." @default.
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• W1971097984 date "1994-01-01" @default.
• W1971097984 modified "2023-10-18" @default.
• W1971097984 title "Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors" @default.
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• W1971097984 doi "https://doi.org/10.1016/0361-9230(94)90104-x" @default.
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