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• W1971109293 abstract "Radiolabeled monoclonal antibodies (MAb) and MAb-streptavidin conjugates exhibit slow blood clearance which impedes radioimmunoimaging and radioimmunotherapy. To control blood clearance and lower background levels, lesion-specific targeting proteins can be modified with galactose derivatives for liver uptake via the hepatocyte galactose receptor. In this study, an isothiocyanate-trigalactose derivative (ITC-Tgal) designed for direct coupling to protein amino groups, was synthesized and characterized. In vitro experimentation demonstrated efficient conjugation of ITC-Tgal to streptavidin (SA) and MAb Fab fragment with a corresponding decrease in protein net charge. In vivo studies were conducted with radiolabeled ITC-Tgal modified and native SA and MAb Fab fragment. ITC-Tgal modified SA and Fab fragment exhibited increased blood clearance with the liver uptake and the rate of blood clearance controlled by the extent of ITC-Tgal modification." @default.
• W1971109293 created "2016-06-24" @default.
• W1971109293 creator A5021893047 @default.
• W1971109293 creator A5066756786 @default.
• W1971109293 date "2000-10-01" @default.
• W1971109293 modified "2023-09-23" @default.
• W1971109293 title "Isothiocyanate-Trigalactose: Application for Antibody-Targeted Delivery of Diagnostic and Therapeutic Agents" @default.
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• W1971109293 doi "https://doi.org/10.1089/cbr.2000.15.507" @default.
• W1971109293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11155822" @default.
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