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- W1971109623 abstract "AbstractGuinea pigs were dermally exposed to 50 mg/kg hexachlorophene (HCP) for 7, 15, and 30 days. Enzymes including alanine and aspartate amino transaminases, gamma glutamyl transpeptidase, β-glucuronidase, and lactic dehydrogenase showed significant increases in liver and kidney. Significant increases were observed in lipid peroxidation, while glutathione content decreased in liver and kidney. The activities of these enzymes also increased in the serum of HCP-exposed animals. On histologic examination the liver showed a moderate degree of congestion, fatty changes, degeneration, and necrosis of hepatocytes. In the kidney desquamation of epithelial cells in the convoluted tubules and foci of mononuclear inflammatory cells and congestion were observed. The biochemical and histopathologic changes were found to be dependent on the duration of exposure." @default.
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- W1971109623 date "1994-01-01" @default.
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- W1971109623 title "Biochemical and Histopathologic Changes in Liver and Kidney of Guinea Pigs Following Dermal Exposure to Hexachlorophene" @default.
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- W1971109623 doi "https://doi.org/10.3109/15569529409037532" @default.
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