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- W1971119380 abstract "We reported recently that the drug methoxsalen, a potent suicide inhibitor of hepatic cytochrome P-450, decreases the metabolic activation of acetaminophen and prevents its hepatotoxicity in mice. We have now studied the effects of methoxsalen on the metabolism of acetaminophen in humans. In vitro , 100 μM methoxsalen decreased by 40% the covalent binding of a [ 3 H]acetaminophen metabolite to microsomal proteins after incubation of [ 3 H]acetaminophen with human liver microsomes and an NADPH-generating system. In vivo , a single oral dose of methoxsalen (30 mg), given 3 hr before acetaminophen (1 g), decreased by 38% the partial apparent oral salivary clearance of acetaminophen into glutathione-derived conjugates (the end products of its oxidative metabolism) in nine human volunteers. These observations demonstrate that methoxsalen decreases the metabolic activation of acetaminophen in humans." @default.
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- W1971119380 date "1987-07-01" @default.
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- W1971119380 title "Effects of methoxsalen on the metabolism of acetaminophen in humans" @default.
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- W1971119380 doi "https://doi.org/10.1016/0006-2952(87)90602-2" @default.
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