Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971122692> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1971122692 endingPage "733" @default.
- W1971122692 startingPage "733" @default.
- W1971122692 abstract "Acute leukaemia is a clonal (that is, derived from a single cell) malignant disorder affecting all age groups from infancy to old age. It is characterised by the accumulation of abnormal white blood cells in the bone marrow which replace normal marrow tissue, including haemopoietic precursor cells. This results in bone marrow failure and peripheral blood involvement. Infiltration of various organs is also a feature of some forms of leukaemia.#### Aetiological factors in acute leukaemiaIn most cases the aetiology is not obvious, but some constitutional and acquired disorders do predispose to acute leukaemia.In the past 40 years advances in the treatment of acute leukaemia have improved the chance of cure from virtually zero to 20-75%, depending on age and type of leukaemia. This has largely been the result of clinical trials—many of which are still ongoing—and the development and continued improvements in bone marrow transplantation.Acute leukaemia is subdivided into ( a ) acute lymphoblastic leukaemia, in which the abnormal proliferation is in the lymphoid progenitor cells (that is, immature lymphocytes) and ( b ) acute myeloid leukaemia, which involves the myeloid lineages (that is, cells from which neutrophils, eosinophils, monocytes, basophils, megakaryocytes, etc are derived). The distinction between the two leukaemias is based on morphological, cytochemical, and immunological differences and is of paramount importance as the treatment and prognosis are usually different.FAB* classification of acute myeloid leukaemiaM0 Acute myeloid leukaemia with minimal evidence of myeloid differentiationM1 Acute myeloblastic leukaemia without maturationM2 Acute myeloblastic leukaemia with maturationM3 Acute promyelocytic leukaemiaM4 Acute myelomonocytic leukaemiaM5 Acute …" @default.
- W1971122692 created "2016-06-24" @default.
- W1971122692 creator A5059264212 @default.
- W1971122692 creator A5061507542 @default.
- W1971122692 date "1997-03-08" @default.
- W1971122692 modified "2023-09-26" @default.
- W1971122692 title "ABC of clinical haematology: The acute leukaemias" @default.
- W1971122692 doi "https://doi.org/10.1136/bmj.314.7082.733" @default.
- W1971122692 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2126141" @default.
- W1971122692 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9116554" @default.
- W1971122692 hasPublicationYear "1997" @default.
- W1971122692 type Work @default.
- W1971122692 sameAs 1971122692 @default.
- W1971122692 citedByCount "20" @default.
- W1971122692 countsByYear W19711226922013 @default.
- W1971122692 countsByYear W19711226922015 @default.
- W1971122692 crossrefType "journal-article" @default.
- W1971122692 hasAuthorship W1971122692A5059264212 @default.
- W1971122692 hasAuthorship W1971122692A5061507542 @default.
- W1971122692 hasBestOaLocation W19711226922 @default.
- W1971122692 hasConcept C121608353 @default.
- W1971122692 hasConcept C126322002 @default.
- W1971122692 hasConcept C177713679 @default.
- W1971122692 hasConcept C194409129 @default.
- W1971122692 hasConcept C2908731994 @default.
- W1971122692 hasConcept C71924100 @default.
- W1971122692 hasConceptScore W1971122692C121608353 @default.
- W1971122692 hasConceptScore W1971122692C126322002 @default.
- W1971122692 hasConceptScore W1971122692C177713679 @default.
- W1971122692 hasConceptScore W1971122692C194409129 @default.
- W1971122692 hasConceptScore W1971122692C2908731994 @default.
- W1971122692 hasConceptScore W1971122692C71924100 @default.
- W1971122692 hasIssue "7082" @default.
- W1971122692 hasLocation W19711226921 @default.
- W1971122692 hasLocation W19711226922 @default.
- W1971122692 hasLocation W19711226923 @default.
- W1971122692 hasLocation W19711226924 @default.
- W1971122692 hasOpenAccess W1971122692 @default.
- W1971122692 hasPrimaryLocation W19711226921 @default.
- W1971122692 hasRelatedWork W1944449512 @default.
- W1971122692 hasRelatedWork W2093630353 @default.
- W1971122692 hasRelatedWork W2185419727 @default.
- W1971122692 hasRelatedWork W2412086637 @default.
- W1971122692 hasRelatedWork W2953928254 @default.
- W1971122692 hasRelatedWork W2955952023 @default.
- W1971122692 hasRelatedWork W3031327055 @default.
- W1971122692 hasRelatedWork W4249866089 @default.
- W1971122692 hasRelatedWork W4379056232 @default.
- W1971122692 hasRelatedWork W1868012796 @default.
- W1971122692 hasVolume "314" @default.
- W1971122692 isParatext "false" @default.
- W1971122692 isRetracted "false" @default.
- W1971122692 magId "1971122692" @default.
- W1971122692 workType "article" @default.