Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971127908> ?p ?o ?g. }
- W1971127908 endingPage "5370" @default.
- W1971127908 startingPage "5363" @default.
- W1971127908 abstract "Breast cancer is the most common carcinoma that metastasizes to bone. To examine the efficacy of recombinant soluble Apo2 ligand (Apo2L)/tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) against breast cancer growth in bone, we established a mouse model in which MDA-MB-231 human breast cancer cells were transplanted directly into the marrow cavity of the tibiae of athymic nude mice producing osteolytic lesions in the area of injection. All vehicle-treated control animals developed large lesions that established in the marrow cavity, eroded the cortical bone, and invaded the surrounding soft tissue, as assessed by radiography, micro-computed tomography, and histology. In contrast, animals treated with recombinant soluble Apo2L/TRAIL showed significant conservation of the tibiae, with 85% reduction in osteolysis, 90% reduction in tumor burden, and no detectable soft tissue invasion. Tumor cells explanted from Apo2L/TRAIL-treated animals were significantly more resistant to the effects of Apo2L/TRAIL when compared with the cells explanted from the vehicle-treated control animals, suggesting that prolonged treatment with Apo2/TRAIL in vivo selects for a resistant phenotype. However, such resistance was readily reversed when Apo2L/TRAIL was used in combination with clinically relevant chemotherapeutic drugs, including taxol, etoposide, doxorubicin, cisplatin, or the histone deacetylase inhibitor suberoylanilide hydroxamic acid. These studies show for the first time that Apo2L/TRAIL can prevent breast cancer-induced bone destruction and highlight the potential of this ligand for the treatment of metastatic breast cancer in bone." @default.
- W1971127908 created "2016-06-24" @default.
- W1971127908 creator A5013717439 @default.
- W1971127908 creator A5056708868 @default.
- W1971127908 creator A5057437913 @default.
- W1971127908 creator A5060420333 @default.
- W1971127908 creator A5060765287 @default.
- W1971127908 creator A5065929346 @default.
- W1971127908 creator A5075623882 @default.
- W1971127908 creator A5063179777 @default.
- W1971127908 creator A5064163849 @default.
- W1971127908 date "2006-05-15" @default.
- W1971127908 modified "2023-10-09" @default.
- W1971127908 title "Apo2l/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Prevents Breast Cancer–Induced Bone Destruction in a Mouse Model" @default.
- W1971127908 cites W1484817497 @default.
- W1971127908 cites W1674551699 @default.
- W1971127908 cites W1978480779 @default.
- W1971127908 cites W1980919524 @default.
- W1971127908 cites W1987154010 @default.
- W1971127908 cites W1993300838 @default.
- W1971127908 cites W2007681284 @default.
- W1971127908 cites W2019465386 @default.
- W1971127908 cites W2021501434 @default.
- W1971127908 cites W2023287155 @default.
- W1971127908 cites W2026987067 @default.
- W1971127908 cites W2032077813 @default.
- W1971127908 cites W2038118195 @default.
- W1971127908 cites W2056217426 @default.
- W1971127908 cites W2077793109 @default.
- W1971127908 cites W2078747183 @default.
- W1971127908 cites W2084390674 @default.
- W1971127908 cites W2084733813 @default.
- W1971127908 cites W2088580558 @default.
- W1971127908 cites W2089476060 @default.
- W1971127908 cites W2092508425 @default.
- W1971127908 cites W2098439946 @default.
- W1971127908 cites W2105186639 @default.
- W1971127908 cites W2105441981 @default.
- W1971127908 cites W2106284224 @default.
- W1971127908 cites W2111807012 @default.
- W1971127908 cites W2113505777 @default.
- W1971127908 cites W2119326933 @default.
- W1971127908 cites W2124992697 @default.
- W1971127908 cites W2130988210 @default.
- W1971127908 cites W2167490100 @default.
- W1971127908 doi "https://doi.org/10.1158/0008-5472.can-05-4386" @default.
- W1971127908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16707463" @default.
- W1971127908 hasPublicationYear "2006" @default.
- W1971127908 type Work @default.
- W1971127908 sameAs 1971127908 @default.
- W1971127908 citedByCount "33" @default.
- W1971127908 countsByYear W19711279082012 @default.
- W1971127908 countsByYear W19711279082013 @default.
- W1971127908 countsByYear W19711279082014 @default.
- W1971127908 countsByYear W19711279082015 @default.
- W1971127908 countsByYear W19711279082017 @default.
- W1971127908 countsByYear W19711279082022 @default.
- W1971127908 crossrefType "journal-article" @default.
- W1971127908 hasAuthorship W1971127908A5013717439 @default.
- W1971127908 hasAuthorship W1971127908A5056708868 @default.
- W1971127908 hasAuthorship W1971127908A5057437913 @default.
- W1971127908 hasAuthorship W1971127908A5060420333 @default.
- W1971127908 hasAuthorship W1971127908A5060765287 @default.
- W1971127908 hasAuthorship W1971127908A5063179777 @default.
- W1971127908 hasAuthorship W1971127908A5064163849 @default.
- W1971127908 hasAuthorship W1971127908A5065929346 @default.
- W1971127908 hasAuthorship W1971127908A5075623882 @default.
- W1971127908 hasConcept C121608353 @default.
- W1971127908 hasConcept C126322002 @default.
- W1971127908 hasConcept C141071460 @default.
- W1971127908 hasConcept C142724271 @default.
- W1971127908 hasConcept C150903083 @default.
- W1971127908 hasConcept C170493617 @default.
- W1971127908 hasConcept C207001950 @default.
- W1971127908 hasConcept C2776033226 @default.
- W1971127908 hasConcept C2776694085 @default.
- W1971127908 hasConcept C2778119113 @default.
- W1971127908 hasConcept C2778239845 @default.
- W1971127908 hasConcept C2780007613 @default.
- W1971127908 hasConcept C2781282405 @default.
- W1971127908 hasConcept C2781303535 @default.
- W1971127908 hasConcept C502942594 @default.
- W1971127908 hasConcept C530470458 @default.
- W1971127908 hasConcept C71924100 @default.
- W1971127908 hasConcept C86803240 @default.
- W1971127908 hasConceptScore W1971127908C121608353 @default.
- W1971127908 hasConceptScore W1971127908C126322002 @default.
- W1971127908 hasConceptScore W1971127908C141071460 @default.
- W1971127908 hasConceptScore W1971127908C142724271 @default.
- W1971127908 hasConceptScore W1971127908C150903083 @default.
- W1971127908 hasConceptScore W1971127908C170493617 @default.
- W1971127908 hasConceptScore W1971127908C207001950 @default.
- W1971127908 hasConceptScore W1971127908C2776033226 @default.
- W1971127908 hasConceptScore W1971127908C2776694085 @default.
- W1971127908 hasConceptScore W1971127908C2778119113 @default.
- W1971127908 hasConceptScore W1971127908C2778239845 @default.
- W1971127908 hasConceptScore W1971127908C2780007613 @default.
- W1971127908 hasConceptScore W1971127908C2781282405 @default.