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• W1971137264 abstract "Summary. Objectives: We speculated that in patients with hypercholesterolemia CD40L overexpression could depend on low-density lipoprotein (LDL)-induced enhanced intraplatelet formation of O2 AE) and statin could reduce platelet CD40L via interference with platelet O2 AE) production. Background: CD40L is a protein with inflammatory and thrombotic properties. CD40L is upregulated in platelets from hypercholesterolemic (HC) patients but the underlying mechanism is unclear. Methods: Collagen-induced platelet CD40L and platelet O2 AE) expression were investigated in 40 HC patients and 40 healthy subjects. HC patients were then randomized to either a diet (n = 20) (group A) or atorvastatin 10 mg day )1 (n = 20) (group B); the above variables were measured at baseline and after 3 and 30 days of treatment. O2 AE) and CD40L were also measured in vitro in LDL-treated platelets with or without nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor or atorvastatin added. Results: Compared with controls, HC patients showed higher values of platelet CD40L (P < 0.001) and O2 AE) (P < 0.001). Platelet CD40L was significantly correlated with O2 AE) (P < 0.001). The interventional trial showed no changes in group A and a significant and parallel decrease in platelet CD40L (P <0 .001) and O2 AE) (P < 0.001) in group B. In vitro studies demonstrated that LDL-induced platelet CD40L and GP IIb/IIIa (PAC1 binding) activation via the NADPH oxidase pathway. CD40L upregulation was counteracted by atorvastatin in a dosedependent fashion. Conclusions: This study suggests that in patients with hypercholesterolemia platelet CD40L is upregulated via NADPH oxidase-dependent O 2 AE) generation. Atorvastatin downregulated CD40L with an oxidative stress-mediated mechanism likely involving platelet NADPH oxidase, an effect that seemed to be independent of its cholesterol-lowering action." @default.
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• W1971137264 date "2007-06-01" @default.
• W1971137264 modified "2023-09-26" @default.
• W1971137264 title "PO22-692 OXIDATIVE STRESS-MEDIATED PLATELET CD40 LIGAND UPREGULATION IN PATIENTS WITH HYPERCHOLESTEROLEMIA. EFFECT OF ATORVASTATIN" @default.
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• W1971137264 doi "https://doi.org/10.1016/s1567-5688(07)71702-6" @default.
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