Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971139739> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1971139739 endingPage "442" @default.
- W1971139739 startingPage "437" @default.
- W1971139739 abstract "This double-blind, placebo-controlled study evaluated the efficacy and safety of sc administered recombinant α2 interferon (IFN-α2)in the suppression of frequently recurrent genital herpes simplex virus (HSV) infection. Seventy-six otherwise healthy subjects who had eight or more recurrences during the preceding year received 1 × 106 IV of IFN-α2, 3 × 106 IV of IFN-α2, or placebo three times per week for 12 weeks. Recipients of the higher dose of IFN-α2, had fewer outbreaks during the study (2 vs. 3), a shorter period of viral shedding (2 vs. 4 days), less itching (1 vs. 3 days), and a faster healing time (6 vs. 8 days). The lower dose of IFN-α2 was not effective. Significant side effects (fever, malaise, myalgia, fatigue, and arthralgia) occurred after the first injection of 3 × 106 IV of IFN-α2 in 91% of the subjects, but subsequent injections produced only mild and intermittent side effects that were well tolerated. Mild leukopenia was noted in subjects treated with IFN-α2, Treatment with IFN-α2 resulted in moderate suppression and decreased duration of recurrent genital HSV infection in patients with frequent recurrences." @default.
- W1971139739 created "2016-06-24" @default.
- W1971139739 creator A5008280183 @default.
- W1971139739 creator A5012774826 @default.
- W1971139739 creator A5020670555 @default.
- W1971139739 creator A5042262326 @default.
- W1971139739 creator A5049277811 @default.
- W1971139739 creator A5053714896 @default.
- W1971139739 creator A5085430278 @default.
- W1971139739 date "1986-09-01" @default.
- W1971139739 modified "2023-10-15" @default.
- W1971139739 title "Suppression of Recurrent Genital Herpes Simplex Virus Infection with Recombinant 2 Interferon" @default.
- W1971139739 doi "https://doi.org/10.1093/infdis/154.3.437" @default.
- W1971139739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3525695" @default.
- W1971139739 hasPublicationYear "1986" @default.
- W1971139739 type Work @default.
- W1971139739 sameAs 1971139739 @default.
- W1971139739 citedByCount "35" @default.
- W1971139739 countsByYear W19711397392022 @default.
- W1971139739 crossrefType "journal-article" @default.
- W1971139739 hasAuthorship W1971139739A5008280183 @default.
- W1971139739 hasAuthorship W1971139739A5012774826 @default.
- W1971139739 hasAuthorship W1971139739A5020670555 @default.
- W1971139739 hasAuthorship W1971139739A5042262326 @default.
- W1971139739 hasAuthorship W1971139739A5049277811 @default.
- W1971139739 hasAuthorship W1971139739A5053714896 @default.
- W1971139739 hasAuthorship W1971139739A5085430278 @default.
- W1971139739 hasConcept C126322002 @default.
- W1971139739 hasConcept C12914427 @default.
- W1971139739 hasConcept C142724271 @default.
- W1971139739 hasConcept C203014093 @default.
- W1971139739 hasConcept C204787440 @default.
- W1971139739 hasConcept C2522874641 @default.
- W1971139739 hasConcept C27081682 @default.
- W1971139739 hasConcept C2776178377 @default.
- W1971139739 hasConcept C2778498788 @default.
- W1971139739 hasConcept C2778616394 @default.
- W1971139739 hasConcept C2779277585 @default.
- W1971139739 hasConcept C2780727368 @default.
- W1971139739 hasConcept C2780873365 @default.
- W1971139739 hasConcept C2781196997 @default.
- W1971139739 hasConcept C2909813250 @default.
- W1971139739 hasConcept C2911196830 @default.
- W1971139739 hasConcept C29730261 @default.
- W1971139739 hasConcept C71924100 @default.
- W1971139739 hasConcept C90924648 @default.
- W1971139739 hasConceptScore W1971139739C126322002 @default.
- W1971139739 hasConceptScore W1971139739C12914427 @default.
- W1971139739 hasConceptScore W1971139739C142724271 @default.
- W1971139739 hasConceptScore W1971139739C203014093 @default.
- W1971139739 hasConceptScore W1971139739C204787440 @default.
- W1971139739 hasConceptScore W1971139739C2522874641 @default.
- W1971139739 hasConceptScore W1971139739C27081682 @default.
- W1971139739 hasConceptScore W1971139739C2776178377 @default.
- W1971139739 hasConceptScore W1971139739C2778498788 @default.
- W1971139739 hasConceptScore W1971139739C2778616394 @default.
- W1971139739 hasConceptScore W1971139739C2779277585 @default.
- W1971139739 hasConceptScore W1971139739C2780727368 @default.
- W1971139739 hasConceptScore W1971139739C2780873365 @default.
- W1971139739 hasConceptScore W1971139739C2781196997 @default.
- W1971139739 hasConceptScore W1971139739C2909813250 @default.
- W1971139739 hasConceptScore W1971139739C2911196830 @default.
- W1971139739 hasConceptScore W1971139739C29730261 @default.
- W1971139739 hasConceptScore W1971139739C71924100 @default.
- W1971139739 hasConceptScore W1971139739C90924648 @default.
- W1971139739 hasIssue "3" @default.
- W1971139739 hasLocation W19711397391 @default.
- W1971139739 hasLocation W19711397392 @default.
- W1971139739 hasOpenAccess W1971139739 @default.
- W1971139739 hasPrimaryLocation W19711397391 @default.
- W1971139739 hasRelatedWork W2155073431 @default.
- W1971139739 hasRelatedWork W2317676378 @default.
- W1971139739 hasRelatedWork W2409107877 @default.
- W1971139739 hasRelatedWork W2413394489 @default.
- W1971139739 hasRelatedWork W2439307995 @default.
- W1971139739 hasRelatedWork W2570704686 @default.
- W1971139739 hasRelatedWork W2729072328 @default.
- W1971139739 hasRelatedWork W4249396943 @default.
- W1971139739 hasRelatedWork W4294867782 @default.
- W1971139739 hasRelatedWork W4306409329 @default.
- W1971139739 hasVolume "154" @default.
- W1971139739 isParatext "false" @default.
- W1971139739 isRetracted "false" @default.
- W1971139739 magId "1971139739" @default.
- W1971139739 workType "article" @default.