Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971142007> ?p ?o ?g. }
- W1971142007 abstract "Lung cancer is the most common cancer in the world. Despite modern advancements in surgeries, chemotherapies, and radiotherapies over the past few years, lung cancer still remains a very difficult disease to treat. This has left the death rate from lung cancer victims largely unchanged throughout the past few decades. A key cause for the high mortality rate is the drug resistance that builds up for patients being currently treated with the chemotherapeutic agents. Although certain chemotherapeutic agents may initially effectively treat lung cancer patients, there is a high probability that there will be a reoccurrence of the cancer after the patient develops resistance to the drug. Erlotinib, the epidermal growth factor receptor (EGFR)-targeting tyrosine kinase inhibitor, has been approved for localized as well as metastatic non-small cell lung cancer where it seems to be more effective in patients with EGFR mutations. Resistance to erlotinib is a common observation in clinics and this review details our current knowledge on the subject. We discuss the causes of such resistance as well as innovative research to overcome it. Evidently, new chemotherapy strategies are desperately needed in order to better treat lung cancer patients. Current research is investigating alternative treatment plans to enhance the chemotherapy that is already offered. Better insight into the molecular mechanisms behind combination therapy pathways and even single molecular pathways may help improve the efficacy of the current treatment options." @default.
- W1971142007 created "2016-06-24" @default.
- W1971142007 creator A5003059995 @default.
- W1971142007 creator A5025836672 @default.
- W1971142007 creator A5042547707 @default.
- W1971142007 creator A5046498573 @default.
- W1971142007 creator A5072765154 @default.
- W1971142007 date "2013-01-01" @default.
- W1971142007 modified "2023-10-16" @default.
- W1971142007 title "Erlotinib Resistance in Lung Cancer: Current Progress and Future Perspectives" @default.
- W1971142007 cites W1249712356 @default.
- W1971142007 cites W1426844501 @default.
- W1971142007 cites W1541310742 @default.
- W1971142007 cites W1821301054 @default.
- W1971142007 cites W1839238860 @default.
- W1971142007 cites W1952952018 @default.
- W1971142007 cites W1967394241 @default.
- W1971142007 cites W1972435958 @default.
- W1971142007 cites W1974024530 @default.
- W1971142007 cites W1981931125 @default.
- W1971142007 cites W1983987902 @default.
- W1971142007 cites W1994857675 @default.
- W1971142007 cites W1997133017 @default.
- W1971142007 cites W1997656349 @default.
- W1971142007 cites W2004718750 @default.
- W1971142007 cites W2012944100 @default.
- W1971142007 cites W2022137080 @default.
- W1971142007 cites W2022212375 @default.
- W1971142007 cites W2023389550 @default.
- W1971142007 cites W2024156010 @default.
- W1971142007 cites W2026023049 @default.
- W1971142007 cites W2026849552 @default.
- W1971142007 cites W2027008275 @default.
- W1971142007 cites W2031810555 @default.
- W1971142007 cites W2037011799 @default.
- W1971142007 cites W2038387569 @default.
- W1971142007 cites W2038934354 @default.
- W1971142007 cites W2040575339 @default.
- W1971142007 cites W2041723923 @default.
- W1971142007 cites W2044905105 @default.
- W1971142007 cites W2046379971 @default.
- W1971142007 cites W2046847797 @default.
- W1971142007 cites W2047946915 @default.
- W1971142007 cites W2051120695 @default.
- W1971142007 cites W2052192635 @default.
- W1971142007 cites W2053439872 @default.
- W1971142007 cites W2059036341 @default.
- W1971142007 cites W2061828956 @default.
- W1971142007 cites W2063156737 @default.
- W1971142007 cites W2064047613 @default.
- W1971142007 cites W2065412623 @default.
- W1971142007 cites W2068122382 @default.
- W1971142007 cites W2069271031 @default.
- W1971142007 cites W2069526613 @default.
- W1971142007 cites W2070150128 @default.
- W1971142007 cites W2073283330 @default.
- W1971142007 cites W2078869486 @default.
- W1971142007 cites W2079251910 @default.
- W1971142007 cites W2081606453 @default.
- W1971142007 cites W2082123847 @default.
- W1971142007 cites W2085419794 @default.
- W1971142007 cites W2086681374 @default.
- W1971142007 cites W2088594738 @default.
- W1971142007 cites W2088842290 @default.
- W1971142007 cites W2091083398 @default.
- W1971142007 cites W2098696935 @default.
- W1971142007 cites W2100912832 @default.
- W1971142007 cites W2101440219 @default.
- W1971142007 cites W2101778620 @default.
- W1971142007 cites W2102583631 @default.
- W1971142007 cites W2103177465 @default.
- W1971142007 cites W2104874286 @default.
- W1971142007 cites W2106787323 @default.
- W1971142007 cites W2107448778 @default.
- W1971142007 cites W2108523633 @default.
- W1971142007 cites W2110530327 @default.
- W1971142007 cites W2112621029 @default.
- W1971142007 cites W2113003672 @default.
- W1971142007 cites W2114095518 @default.
- W1971142007 cites W2114327665 @default.
- W1971142007 cites W2118113452 @default.
- W1971142007 cites W2119366998 @default.
- W1971142007 cites W2120334178 @default.
- W1971142007 cites W2122553809 @default.
- W1971142007 cites W2124797061 @default.
- W1971142007 cites W2125579284 @default.
- W1971142007 cites W2126188779 @default.
- W1971142007 cites W2126277347 @default.
- W1971142007 cites W2127955519 @default.
- W1971142007 cites W2134667653 @default.
- W1971142007 cites W2135422811 @default.
- W1971142007 cites W2136023414 @default.
- W1971142007 cites W2136263263 @default.
- W1971142007 cites W2136390065 @default.
- W1971142007 cites W2138297714 @default.
- W1971142007 cites W2139163037 @default.
- W1971142007 cites W2139236349 @default.
- W1971142007 cites W2140021827 @default.
- W1971142007 cites W2141635226 @default.
- W1971142007 cites W2142436130 @default.