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• W1971154814 abstract "Gilbert syndrome (GS) is an inherited defect of bilirubin conjugation, most commonly caused by a gene mutation for the enzyme UGT1A. GS is known to affect the metabolism and excretion of drugs and xenobiotics. Perfluorocarbon compounds (PFCs) are bio-persistent environmental contaminants that affect metabolic regulation. In this study, we examined the associations of GS phenotype and serum PFCs in the C8 Health Study Population.Using 2005-2006 data from a large PFC-exposure population survey, we compared serum PFCs concentrations between GS and non GS clinical phenotypes, in a cross sectional design, adjusting for standard risk factors, including age, BMI, smoking status, socioeconomic status and gender.Among 10 PFC compounds considered, only perfluorohexanoic acid (PFHxA) was seen at a significantly higher concentration in GS men and women.PFHxA exposure may be associated with GS. Our findings do not support increased exposure in GS for other PFCs." @default.
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• W1971154814 date "2014-11-01" @default.
• W1971154814 modified "2023-09-25" @default.
• W1971154814 title "Perfluorocarbons and Gilbert syndrome (phenotype) in the C8 Health Study Population" @default.
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• W1971154814 doi "https://doi.org/10.1016/j.envres.2014.08.011" @default.
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