FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971162669> ?p ?o ?g. }

• W1971162669 endingPage "122" @default.
• W1971162669 startingPage "118" @default.
• W1971162669 abstract "To evaluate the role of the dialysate in the stimulation of interleukin-1 (IL-1) production during clinical hemodialysis (HD), we studied maintenance HD patients in two experiments. Cellulosic hollow-fiber dialyzers were obtained after 20 minutes of HD using either nonsterile standard dialysate (n = 6) or sterile pyrogen free 0.9% saline as dialysate (n = 6). After rinsing the blood compartment with normal saline, dialyzers were incubated at 37°C for six hours. Aliquots from the blood compartment were analyzed for the presence of IL-1 by (1) rabbit pyrogenic response after intravenous injection or (2) thymocyte co-proliferation assay. The in vivo assay showed a significantly greater febrile response when standard dialysate was used than in the sterile saline group (P < .001), and this response could be abolished by heat inactivation of aliquots (P < .001). The in vitro assay confirmed the presence of significantly greater amounts of IL-1 (P < .05). Studies were repeated using filter sterilized standard dialysate (n = 6) v standard dialysate (n = 6) for 240 minutes of clinical HD. The in vitro assay revealed significantly lower IL-1 levels in the filtered sterilized dialysate group (P < .05), however, a blank control assay showed yet significantly lower levels (P < .05). We conclude that IL-1 is produced during clinical HD and that endotoxin or its fragments play a role in the stimulation of IL-1 production, probably through monocytes adhering to the dialysis membrane. In addition to this dialysate factor, IL-1 production appears also to be stimulated by a blood-membrane interaction. To evaluate the role of the dialysate in the stimulation of interleukin-1 (IL-1) production during clinical hemodialysis (HD), we studied maintenance HD patients in two experiments. Cellulosic hollow-fiber dialyzers were obtained after 20 minutes of HD using either nonsterile standard dialysate (n = 6) or sterile pyrogen free 0.9% saline as dialysate (n = 6). After rinsing the blood compartment with normal saline, dialyzers were incubated at 37°C for six hours. Aliquots from the blood compartment were analyzed for the presence of IL-1 by (1) rabbit pyrogenic response after intravenous injection or (2) thymocyte co-proliferation assay. The in vivo assay showed a significantly greater febrile response when standard dialysate was used than in the sterile saline group (P < .001), and this response could be abolished by heat inactivation of aliquots (P < .001). The in vitro assay confirmed the presence of significantly greater amounts of IL-1 (P < .05). Studies were repeated using filter sterilized standard dialysate (n = 6) v standard dialysate (n = 6) for 240 minutes of clinical HD. The in vitro assay revealed significantly lower IL-1 levels in the filtered sterilized dialysate group (P < .05), however, a blank control assay showed yet significantly lower levels (P < .05). We conclude that IL-1 is produced during clinical HD and that endotoxin or its fragments play a role in the stimulation of IL-1 production, probably through monocytes adhering to the dialysis membrane. In addition to this dialysate factor, IL-1 production appears also to be stimulated by a blood-membrane interaction." @default.
• W1971162669 created "2016-06-24" @default.
• W1971162669 creator A5004928457 @default.
• W1971162669 creator A5013202142 @default.
• W1971162669 creator A5030108119 @default.
• W1971162669 creator A5035826601 @default.
• W1971162669 date "1987-08-01" @default.
• W1971162669 modified "2023-09-23" @default.
• W1971162669 title "The Role of Dialysate in the Stimulation of Interleukin-1 Production During Clinical Hemodialysis" @default.
• W1971162669 cites W1998168979 @default.
• W1971162669 cites W1998362817 @default.
• W1971162669 cites W2001870721 @default.
• W1971162669 cites W2006395983 @default.
• W1971162669 cites W2015955793 @default.
• W1971162669 cites W2021496976 @default.
• W1971162669 cites W2066797641 @default.
• W1971162669 cites W2067964757 @default.
• W1971162669 cites W2075340236 @default.
• W1971162669 cites W2078428323 @default.
• W1971162669 cites W2120450410 @default.
• W1971162669 cites W2255621825 @default.
• W1971162669 cites W4206163632 @default.
• W1971162669 cites W4238521338 @default.
• W1971162669 cites W4293569363 @default.
• W1971162669 doi "https://doi.org/10.1016/s0272-6386(87)80043-4" @default.
• W1971162669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3496789" @default.
• W1971162669 hasPublicationYear "1987" @default.
• W1971162669 type Work @default.
• W1971162669 sameAs 1971162669 @default.
• W1971162669 citedByCount "41" @default.
• W1971162669 countsByYear W19711626692015 @default.
• W1971162669 countsByYear W19711626692019 @default.
• W1971162669 crossrefType "journal-article" @default.
• W1971162669 hasAuthorship W1971162669A5004928457 @default.
• W1971162669 hasAuthorship W1971162669A5013202142 @default.
• W1971162669 hasAuthorship W1971162669A5030108119 @default.
• W1971162669 hasAuthorship W1971162669A5035826601 @default.
• W1971162669 hasConcept C126322002 @default.
• W1971162669 hasConcept C150903083 @default.
• W1971162669 hasConcept C1621761 @default.
• W1971162669 hasConcept C16685009 @default.
• W1971162669 hasConcept C185592680 @default.
• W1971162669 hasConcept C202751555 @default.
• W1971162669 hasConcept C207001950 @default.
• W1971162669 hasConcept C24998067 @default.
• W1971162669 hasConcept C2777397205 @default.
• W1971162669 hasConcept C2778063415 @default.
• W1971162669 hasConcept C2778690821 @default.
• W1971162669 hasConcept C2779978075 @default.
• W1971162669 hasConcept C55493867 @default.
• W1971162669 hasConcept C71924100 @default.
• W1971162669 hasConcept C74172505 @default.
• W1971162669 hasConcept C86803240 @default.
• W1971162669 hasConceptScore W1971162669C126322002 @default.
• W1971162669 hasConceptScore W1971162669C150903083 @default.
• W1971162669 hasConceptScore W1971162669C1621761 @default.
• W1971162669 hasConceptScore W1971162669C16685009 @default.
• W1971162669 hasConceptScore W1971162669C185592680 @default.
• W1971162669 hasConceptScore W1971162669C202751555 @default.
• W1971162669 hasConceptScore W1971162669C207001950 @default.
• W1971162669 hasConceptScore W1971162669C24998067 @default.
• W1971162669 hasConceptScore W1971162669C2777397205 @default.
• W1971162669 hasConceptScore W1971162669C2778063415 @default.
• W1971162669 hasConceptScore W1971162669C2778690821 @default.
• W1971162669 hasConceptScore W1971162669C2779978075 @default.
• W1971162669 hasConceptScore W1971162669C55493867 @default.
• W1971162669 hasConceptScore W1971162669C71924100 @default.
• W1971162669 hasConceptScore W1971162669C74172505 @default.
• W1971162669 hasConceptScore W1971162669C86803240 @default.
• W1971162669 hasIssue "2" @default.
• W1971162669 hasLocation W19711626691 @default.
• W1971162669 hasLocation W19711626692 @default.
• W1971162669 hasOpenAccess W1971162669 @default.
• W1971162669 hasPrimaryLocation W19711626691 @default.
• W1971162669 hasRelatedWork W113810927 @default.
• W1971162669 hasRelatedWork W1964487184 @default.
• W1971162669 hasRelatedWork W1987944709 @default.
• W1971162669 hasRelatedWork W1997868327 @default.
• W1971162669 hasRelatedWork W2000501579 @default.
• W1971162669 hasRelatedWork W2011384323 @default.
• W1971162669 hasRelatedWork W2025499134 @default.
• W1971162669 hasRelatedWork W2031575817 @default.
• W1971162669 hasRelatedWork W3135058361 @default.
• W1971162669 hasRelatedWork W40023729 @default.
• W1971162669 hasVolume "10" @default.
• W1971162669 isParatext "false" @default.
• W1971162669 isRetracted "false" @default.
• W1971162669 magId "1971162669" @default.
• W1971162669 workType "article" @default.