FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971165963> ?p ?o ?g. }

• W1971165963 endingPage "496" @default.
• W1971165963 startingPage "490" @default.
• W1971165963 abstract "Summary: Purpose: Carbamazepine (CBZ) and oxcarbazepine (OXCZ) are well‐known inducers of drug metabolism via CYP3A4. Indirect interaction studies and clinical experience suggest that CBZ has a stronger potential in this regard than OXCZ. However this has never been subject to a direct comparative study. We performed a study in healthy volunteers to investigate the relative inductive effect of CBZ and OXCZ on CYP3A4 activity using the metabolism of quinidine as a biomarker reaction. Methods: Ten healthy, male volunteers participated in an open, randomized crossover study consisting of two periods separated by a 4‐week wash‐out period. The subjects received 1200 mg oral OXCZ daily for 17 days and 800 mg oral CBZ for 17 days. A single 200 mg oral dose of quinidine was administered at baseline and following administration of CBZ and OXCZ. Outcome parameters were the formation clearance of 3‐hydroxyquinidine dose and the ratio of the AUCs of 3‐hydroxyquinidine to quinidine. Results: Formation clearance of 3‐hydroxyquinidine was increased by means of 89% (CI: 36–164; p = 0.0022) and 181% (CI: 120–260, p < 0.0001) after treatment with OXCZ and CBZ, respectively, compared to baseline. The relative inductive effect of CBZ was 46% higher than for OXCZ. AUC ratio increased by means of 161% (CI: 139–187, p < 0.0001) (OXCZ) and 222% (CI: 192–257, p < 0.0001) (CBZ). Quinidine Cmax decreased by means of 29% (CI: 16–40, p = 0.0018) (OXCZ) and 33% (CI: 18–45, p = 0.0020) (CBZ). T ½ decreased by means of 12% (CI: 6–17, p < 0.0014) (OXCZ) and 32% (CI: 25–38, p < 0.0001) (CBZ). t max was not changed in either period. Conclusion: We confirm a clinically significant inductive effect of both OXCZ and CBZ. The inductive effect of CBZ was about 46% higher than that of OXCZ, a difference that may be of clinical relevance." @default.
• W1971165963 created "2016-06-24" @default.
• W1971165963 creator A5053033359 @default.
• W1971165963 creator A5059718242 @default.
• W1971165963 creator A5082943186 @default.
• W1971165963 date "2007-03-01" @default.
• W1971165963 modified "2023-10-17" @default.
• W1971165963 title "A Comparative Pharmacokinetic Study in Healthy Volunteers of the Effect of Carbamazepine and Oxcarbazepine on Cyp3a4" @default.
• W1971165963 cites W1569270003 @default.
• W1971165963 cites W1591974123 @default.
• W1971165963 cites W1956099131 @default.
• W1971165963 cites W1967322264 @default.
• W1971165963 cites W1977480533 @default.
• W1971165963 cites W1984381869 @default.
• W1971165963 cites W1985155015 @default.
• W1971165963 cites W1992701784 @default.
• W1971165963 cites W2001063427 @default.
• W1971165963 cites W2005876531 @default.
• W1971165963 cites W2006051291 @default.
• W1971165963 cites W2023533579 @default.
• W1971165963 cites W2023938946 @default.
• W1971165963 cites W2024920292 @default.
• W1971165963 cites W2033336706 @default.
• W1971165963 cites W2039687483 @default.
• W1971165963 cites W2049772989 @default.
• W1971165963 cites W2050771152 @default.
• W1971165963 cites W2059036925 @default.
• W1971165963 cites W2059573002 @default.
• W1971165963 cites W2073975093 @default.
• W1971165963 cites W2083014745 @default.
• W1971165963 cites W2091057921 @default.
• W1971165963 cites W2091595427 @default.
• W1971165963 cites W2097502628 @default.
• W1971165963 cites W2104489235 @default.
• W1971165963 cites W2131115349 @default.
• W1971165963 cites W2132001275 @default.
• W1971165963 cites W2166513726 @default.
• W1971165963 doi "https://doi.org/10.1111/j.1528-1167.2007.00924.x" @default.
• W1971165963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17346248" @default.
• W1971165963 hasPublicationYear "2007" @default.
• W1971165963 type Work @default.
• W1971165963 sameAs 1971165963 @default.
• W1971165963 citedByCount "54" @default.
• W1971165963 countsByYear W19711659632012 @default.
• W1971165963 countsByYear W19711659632013 @default.
• W1971165963 countsByYear W19711659632014 @default.
• W1971165963 countsByYear W19711659632015 @default.
• W1971165963 countsByYear W19711659632016 @default.
• W1971165963 countsByYear W19711659632017 @default.
• W1971165963 countsByYear W19711659632018 @default.
• W1971165963 countsByYear W19711659632019 @default.
• W1971165963 countsByYear W19711659632020 @default.
• W1971165963 countsByYear W19711659632021 @default.
• W1971165963 countsByYear W19711659632022 @default.
• W1971165963 countsByYear W19711659632023 @default.
• W1971165963 crossrefType "journal-article" @default.
• W1971165963 hasAuthorship W1971165963A5053033359 @default.
• W1971165963 hasAuthorship W1971165963A5059718242 @default.
• W1971165963 hasAuthorship W1971165963A5082943186 @default.
• W1971165963 hasBestOaLocation W19711659631 @default.
• W1971165963 hasConcept C109650736 @default.
• W1971165963 hasConcept C112705442 @default.
• W1971165963 hasConcept C118552586 @default.
• W1971165963 hasConcept C126322002 @default.
• W1971165963 hasConcept C142724271 @default.
• W1971165963 hasConcept C204787440 @default.
• W1971165963 hasConcept C22979827 @default.
• W1971165963 hasConcept C27081682 @default.
• W1971165963 hasConcept C2775858608 @default.
• W1971165963 hasConcept C2777056448 @default.
• W1971165963 hasConcept C2778186239 @default.
• W1971165963 hasConcept C2779253243 @default.
• W1971165963 hasConcept C2780339425 @default.
• W1971165963 hasConcept C2781176495 @default.
• W1971165963 hasConcept C526171541 @default.
• W1971165963 hasConcept C62231903 @default.
• W1971165963 hasConcept C71924100 @default.
• W1971165963 hasConcept C87813604 @default.
• W1971165963 hasConcept C97320921 @default.
• W1971165963 hasConcept C98274493 @default.
• W1971165963 hasConceptScore W1971165963C109650736 @default.
• W1971165963 hasConceptScore W1971165963C112705442 @default.
• W1971165963 hasConceptScore W1971165963C118552586 @default.
• W1971165963 hasConceptScore W1971165963C126322002 @default.
• W1971165963 hasConceptScore W1971165963C142724271 @default.
• W1971165963 hasConceptScore W1971165963C204787440 @default.
• W1971165963 hasConceptScore W1971165963C22979827 @default.
• W1971165963 hasConceptScore W1971165963C27081682 @default.
• W1971165963 hasConceptScore W1971165963C2775858608 @default.
• W1971165963 hasConceptScore W1971165963C2777056448 @default.
• W1971165963 hasConceptScore W1971165963C2778186239 @default.
• W1971165963 hasConceptScore W1971165963C2779253243 @default.
• W1971165963 hasConceptScore W1971165963C2780339425 @default.
• W1971165963 hasConceptScore W1971165963C2781176495 @default.
• W1971165963 hasConceptScore W1971165963C526171541 @default.
• W1971165963 hasConceptScore W1971165963C62231903 @default.
• W1971165963 hasConceptScore W1971165963C71924100 @default.
• W1971165963 hasConceptScore W1971165963C87813604 @default.

• next