Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971174449> ?p ?o ?g. }
- W1971174449 endingPage "1986" @default.
- W1971174449 startingPage "1979" @default.
- W1971174449 abstract "In recent years, there has been a surge of interest in magnesium (Mg) and its alloys as biomaterials for orthopaedic applications, as they possess desirable mechanical properties, good biocompatibility, and biodegradability. Also shown to be osteoinductive, Mg-based materials could be particularly advantageous in functional tissue engineering to improve healing and serve as scaffolds for delivery of drugs, cells, and cytokines. In this paper, we will present two examples of Mg-based orthopaedic devices: an interference screw to accelerate ACL graft healing and a ring to aid in the healing of an injured ACL. In vitro tests using a robotic/UFS testing system showed that both devices could restore function of the goat stifle joint. Under a 67-N anterior tibial load, both the ACL graft fixed with the Mg-based interference screw and the Mg-based ring-repaired ACL could restore anterior tibial translation (ATT) to within 2 mm and 5 mm, respectively, of the intact joint at 30°, 60°, and 90° of flexion. In-situ forces in the replacement graft and Mg-based ring-repaired ACL were also similar to those of the intact ACL. Further, early in vivo data using the Mg-based interference screw showed that after 12 weeks, it was non-toxic and the joint stability and graft function reached similar levels as published data. Following these positive results, we will move forward in incorporating bioactive molecules and ECM bioscaffolds to these Mg-based biomaterials to test their potential for functional tissue engineering of musculoskeletal and other tissues." @default.
- W1971174449 created "2016-06-24" @default.
- W1971174449 creator A5034013890 @default.
- W1971174449 creator A5055659290 @default.
- W1971174449 creator A5056023028 @default.
- W1971174449 creator A5060488910 @default.
- W1971174449 creator A5080391472 @default.
- W1971174449 date "2014-06-01" @default.
- W1971174449 modified "2023-10-12" @default.
- W1971174449 title "Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering" @default.
- W1971174449 cites W1500260296 @default.
- W1971174449 cites W1937547426 @default.
- W1971174449 cites W1943339244 @default.
- W1971174449 cites W1945520291 @default.
- W1971174449 cites W1967296036 @default.
- W1971174449 cites W1983436829 @default.
- W1971174449 cites W1991642422 @default.
- W1971174449 cites W1996185929 @default.
- W1971174449 cites W2008158617 @default.
- W1971174449 cites W2011634501 @default.
- W1971174449 cites W2013112390 @default.
- W1971174449 cites W2015322203 @default.
- W1971174449 cites W202137580 @default.
- W1971174449 cites W2023977237 @default.
- W1971174449 cites W2024935667 @default.
- W1971174449 cites W2028107824 @default.
- W1971174449 cites W2029404003 @default.
- W1971174449 cites W2051875423 @default.
- W1971174449 cites W2052616514 @default.
- W1971174449 cites W2053105488 @default.
- W1971174449 cites W2055248506 @default.
- W1971174449 cites W2059551976 @default.
- W1971174449 cites W2059896455 @default.
- W1971174449 cites W2064538918 @default.
- W1971174449 cites W2065584958 @default.
- W1971174449 cites W2069404503 @default.
- W1971174449 cites W2069468296 @default.
- W1971174449 cites W2071828000 @default.
- W1971174449 cites W2075343185 @default.
- W1971174449 cites W2075502012 @default.
- W1971174449 cites W2077528414 @default.
- W1971174449 cites W2084498917 @default.
- W1971174449 cites W2084610464 @default.
- W1971174449 cites W2086192467 @default.
- W1971174449 cites W2095661795 @default.
- W1971174449 cites W2101245520 @default.
- W1971174449 cites W2105888628 @default.
- W1971174449 cites W2106242481 @default.
- W1971174449 cites W2113970858 @default.
- W1971174449 cites W2116506624 @default.
- W1971174449 cites W2127106256 @default.
- W1971174449 cites W2134515785 @default.
- W1971174449 cites W2136691001 @default.
- W1971174449 cites W2148910340 @default.
- W1971174449 cites W2156622891 @default.
- W1971174449 cites W2160855647 @default.
- W1971174449 cites W4248075357 @default.
- W1971174449 doi "https://doi.org/10.1016/j.jbiomech.2013.12.003" @default.
- W1971174449 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4144980" @default.
- W1971174449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24373510" @default.
- W1971174449 hasPublicationYear "2014" @default.
- W1971174449 type Work @default.
- W1971174449 sameAs 1971174449 @default.
- W1971174449 citedByCount "167" @default.
- W1971174449 countsByYear W19711744492014 @default.
- W1971174449 countsByYear W19711744492015 @default.
- W1971174449 countsByYear W19711744492016 @default.
- W1971174449 countsByYear W19711744492017 @default.
- W1971174449 countsByYear W19711744492018 @default.
- W1971174449 countsByYear W19711744492019 @default.
- W1971174449 countsByYear W19711744492020 @default.
- W1971174449 countsByYear W19711744492021 @default.
- W1971174449 countsByYear W19711744492022 @default.
- W1971174449 countsByYear W19711744492023 @default.
- W1971174449 crossrefType "journal-article" @default.
- W1971174449 hasAuthorship W1971174449A5034013890 @default.
- W1971174449 hasAuthorship W1971174449A5055659290 @default.
- W1971174449 hasAuthorship W1971174449A5056023028 @default.
- W1971174449 hasAuthorship W1971174449A5060488910 @default.
- W1971174449 hasAuthorship W1971174449A5080391472 @default.
- W1971174449 hasBestOaLocation W19711744492 @default.
- W1971174449 hasConcept C136229726 @default.
- W1971174449 hasConcept C141071460 @default.
- W1971174449 hasConcept C150903083 @default.
- W1971174449 hasConcept C191897082 @default.
- W1971174449 hasConcept C192562407 @default.
- W1971174449 hasConcept C207001950 @default.
- W1971174449 hasConcept C2776626428 @default.
- W1971174449 hasConcept C2777230088 @default.
- W1971174449 hasConcept C2778434673 @default.
- W1971174449 hasConcept C2779699715 @default.
- W1971174449 hasConcept C49892992 @default.
- W1971174449 hasConcept C71924100 @default.
- W1971174449 hasConcept C86803240 @default.
- W1971174449 hasConceptScore W1971174449C136229726 @default.
- W1971174449 hasConceptScore W1971174449C141071460 @default.
- W1971174449 hasConceptScore W1971174449C150903083 @default.
- W1971174449 hasConceptScore W1971174449C191897082 @default.