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- W1971186239 abstract "Cerebral malaria (CM) is still a major world health problem whose pathogenic mechanisms remain incompletely understood. After reviewing some particularities of anti-malarial immunity, we focus here on the neurovascular aspects of CM. We specifically address the central role of endothelial activation and alteration in disease pathogenesis. We discuss the respective roles of mediator-induced versus host cell-induced mechanisms of endothelial alteration. The former include cytokines, chemokines and their receptors, while the latter encompass cells located inside and outside the vessel, notably glial cells. We also present evidence for a pathogenic role for membrane microparticles (MP) in CM, based on studies in African patients and in a recognised mouse model. Intervention studies on MP production, via either gene knockout or pharmacological inhibition, can prevent the neurological syndrome and its associated mortality, suggesting potential new therapeutic avenues." @default.
- W1971186239 created "2016-06-24" @default.
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- W1971186239 creator A5086272051 @default.
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- W1971186239 date "2010-06-01" @default.
- W1971186239 modified "2023-10-16" @default.
- W1971186239 title "Microvesiculation and cell interactions at the brain–endothelial interface in cerebral malaria pathogenesis" @default.
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