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• W1971222773 abstract "The effect of amiodarone on Na + /Ca 2+ exchange current (I NCX ) was examined in single guinea‐pig ventricular myocytes using the whole‐cell voltage clamp technique. I NCX was recorded by ramp pulses from the holding potential of −60 mV in the presence of 140 m M Na + and 2 m M Ca 2+ in the external solution, and 20 m M Na + and 398 n M free Ca 2+ (19 m M Ca 2+ and 30 m M BAPTA) in the internal solution. External application of amiodarone suppressed I NCX in a concentration‐dependent manner. The IC 50 value was 3.3 μ M with a Hill coefficient of 1. Intracellular application of trypsin via the micropipette attenuated the blocking effect of amiodarone, suggesting that amiodarone affects the cytoplasmic side of the molecule. This inhibitory effect of amiodarone on the Na + /Ca 2+ exchanger may contribute to the cardioprotective action of the drug. British Journal of Pharmacology (2000) 131 , 80–84; doi: 10.1038/sj.bjp.0703527" @default.
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• W1971222773 date "2000-09-01" @default.
• W1971222773 modified "2023-10-17" @default.
• W1971222773 title "Inhibitory effect of amiodarone on Na⁺/Ca²⁺ exchange current in guinea‐pig cardiac myocytes" @default.
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• W1971222773 doi "https://doi.org/10.1038/sj.bjp.0703527" @default.
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