Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971234076> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1971234076 endingPage "158" @default.
- W1971234076 startingPage "153" @default.
- W1971234076 abstract "The lack of a therapeutic effect or unsupportable side-effects can lead to substitution of one antidepressant by another. The present study investigated potential modifications to the pharmacokinetic profile of milnacipran at steady-state when it is substituted for fluoxetine without any washout period. The open-label, multiple dose, three-period study was carried out in 12 evaluable healthy volunteers. A reference period (period 1) comprising a 3.5-day treatment with milnacipran at 50 mg b.i.d. was followed, after a 5–10-day washout, by 3 weeks of administration of 20 mg fluoxetine once daily (period 2), immediately followed by a further 3.5 days of administration of milnacipran at 50 mg b.i.d. (period 3). Blood samples collected at each period were analysed for milnacipran, N-dealkyl milnacipran, fluoxetine and norfluoxetine. Potential drug–drug interactions were evaluated by comparing milnacipran pharmacokinetic parameters between periods 1 and 3. A steady-state of fluoxetine and its metabolite was effectively reached by the end of the 3-week period. A steady-state of milnacipran was reached on day 2 of both periods 1 and 3. Trough concentrations of milnacipran were 66 and 65 ng/ml before and after the fluoxetine administration period, respectively. Cmax values were 226 and 248 ng/ml. When comparing the kinetic parameters of milnacipran before and after fluoxetine treatment, all the 90% confidence intervals were in the 20% range. No significant difference in the adverse events of milnacipran was observed before or after fluoxetine administration." @default.
- W1971234076 created "2016-06-24" @default.
- W1971234076 creator A5002047733 @default.
- W1971234076 creator A5006933051 @default.
- W1971234076 creator A5012083106 @default.
- W1971234076 date "2006-05-01" @default.
- W1971234076 modified "2023-10-18" @default.
- W1971234076 title "Lack of pharmacokinetic interaction when switching from fluoxetine to milnacipran" @default.
- W1971234076 cites W1968616140 @default.
- W1971234076 cites W1994371881 @default.
- W1971234076 cites W2005244872 @default.
- W1971234076 cites W2032865655 @default.
- W1971234076 cites W2045654730 @default.
- W1971234076 cites W2057657052 @default.
- W1971234076 cites W2081344727 @default.
- W1971234076 cites W2089858686 @default.
- W1971234076 cites W2117809065 @default.
- W1971234076 cites W2313825065 @default.
- W1971234076 cites W4233714330 @default.
- W1971234076 cites W4244171682 @default.
- W1971234076 doi "https://doi.org/10.1097/01.yic.0000188217.69537.dc" @default.
- W1971234076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16528137" @default.
- W1971234076 hasPublicationYear "2006" @default.
- W1971234076 type Work @default.
- W1971234076 sameAs 1971234076 @default.
- W1971234076 citedByCount "9" @default.
- W1971234076 countsByYear W19712340762012 @default.
- W1971234076 countsByYear W19712340762020 @default.
- W1971234076 crossrefType "journal-article" @default.
- W1971234076 hasAuthorship W1971234076A5002047733 @default.
- W1971234076 hasAuthorship W1971234076A5006933051 @default.
- W1971234076 hasAuthorship W1971234076A5012083106 @default.
- W1971234076 hasConcept C112705442 @default.
- W1971234076 hasConcept C126322002 @default.
- W1971234076 hasConcept C149151106 @default.
- W1971234076 hasConcept C170493617 @default.
- W1971234076 hasConcept C185592680 @default.
- W1971234076 hasConcept C2775864247 @default.
- W1971234076 hasConcept C2776134451 @default.
- W1971234076 hasConcept C2777477808 @default.
- W1971234076 hasConcept C2779177272 @default.
- W1971234076 hasConcept C2780199185 @default.
- W1971234076 hasConcept C2781161787 @default.
- W1971234076 hasConcept C31487548 @default.
- W1971234076 hasConcept C42219234 @default.
- W1971234076 hasConcept C55493867 @default.
- W1971234076 hasConcept C71924100 @default.
- W1971234076 hasConcept C98274493 @default.
- W1971234076 hasConceptScore W1971234076C112705442 @default.
- W1971234076 hasConceptScore W1971234076C126322002 @default.
- W1971234076 hasConceptScore W1971234076C149151106 @default.
- W1971234076 hasConceptScore W1971234076C170493617 @default.
- W1971234076 hasConceptScore W1971234076C185592680 @default.
- W1971234076 hasConceptScore W1971234076C2775864247 @default.
- W1971234076 hasConceptScore W1971234076C2776134451 @default.
- W1971234076 hasConceptScore W1971234076C2777477808 @default.
- W1971234076 hasConceptScore W1971234076C2779177272 @default.
- W1971234076 hasConceptScore W1971234076C2780199185 @default.
- W1971234076 hasConceptScore W1971234076C2781161787 @default.
- W1971234076 hasConceptScore W1971234076C31487548 @default.
- W1971234076 hasConceptScore W1971234076C42219234 @default.
- W1971234076 hasConceptScore W1971234076C55493867 @default.
- W1971234076 hasConceptScore W1971234076C71924100 @default.
- W1971234076 hasConceptScore W1971234076C98274493 @default.
- W1971234076 hasIssue "3" @default.
- W1971234076 hasLocation W19712340761 @default.
- W1971234076 hasLocation W19712340762 @default.
- W1971234076 hasOpenAccess W1971234076 @default.
- W1971234076 hasPrimaryLocation W19712340761 @default.
- W1971234076 hasRelatedWork W1964759623 @default.
- W1971234076 hasRelatedWork W1975213559 @default.
- W1971234076 hasRelatedWork W1986601193 @default.
- W1971234076 hasRelatedWork W2031210349 @default.
- W1971234076 hasRelatedWork W2036084056 @default.
- W1971234076 hasRelatedWork W2081460129 @default.
- W1971234076 hasRelatedWork W2132691174 @default.
- W1971234076 hasRelatedWork W2167945809 @default.
- W1971234076 hasRelatedWork W2266390655 @default.
- W1971234076 hasRelatedWork W2375091710 @default.
- W1971234076 hasVolume "21" @default.
- W1971234076 isParatext "false" @default.
- W1971234076 isRetracted "false" @default.
- W1971234076 magId "1971234076" @default.
- W1971234076 workType "article" @default.