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• W1971234495 abstract "Rationale and Objectives. We compared the peritumoral vascular definition in rats using either a paramagnetic extracellular or a macromolecular contrast medium in combination with high-resolution magnetic resonance (MR) imaging. Methods. High-resolution, three-dimensional spoiled gradient-refocused acquisition in a steady state (SPGR) images were acquired from tumor-bearing Fischer-344 rats before, immediately after, and again 40 min after administration of gadopentetate dimeglumine (0.1 mmol Gd/kg; n = 10) and albumin-(Gd-DTPA)30 (0.05 mmol Gd/kg; n = 5). Small peritumoral vessels were analyzed semiquantitatively on maximum intensity projection angiograms using a 4-point scoring system; quantitative analyses included signal-to-background ratios (SBRs) and signal-to-noise ratios. Results. Gadopentetate dimeglumine caused a transient and low-scoring (0.2 ± 0.1, SBR = 1.9 ± 0.2) vessel definition but strong rim enhancement (score = 1.4 ± 0.2). Albumin-(Gd-DTPA)30 produced persistent, high-quality angiograms (score = 2.6 ± 0.2, SBR = 7.4 ± 0.2) but minimal rim enhancement (score = 0.3 ± 0.2). Conclusion. Albumin-(Gd-DTPA)30 combined with high-resolution MR imaging produces time-persistent, detailed angiographic definition of peritumoral vessels. Vascular maps obtained with gadopentetate dimeglumine enhancement are not time persistent or of equal quality. We compared the peritumoral vascular definition in rats using either a paramagnetic extracellular or a macromolecular contrast medium in combination with high-resolution magnetic resonance (MR) imaging. High-resolution, three-dimensional spoiled gradient-refocused acquisition in a steady state (SPGR) images were acquired from tumor-bearing Fischer-344 rats before, immediately after, and again 40 min after administration of gadopentetate dimeglumine (0.1 mmol Gd/kg; n = 10) and albumin-(Gd-DTPA)30 (0.05 mmol Gd/kg; n = 5). Small peritumoral vessels were analyzed semiquantitatively on maximum intensity projection angiograms using a 4-point scoring system; quantitative analyses included signal-to-background ratios (SBRs) and signal-to-noise ratios. Gadopentetate dimeglumine caused a transient and low-scoring (0.2 ± 0.1, SBR = 1.9 ± 0.2) vessel definition but strong rim enhancement (score = 1.4 ± 0.2). Albumin-(Gd-DTPA)30 produced persistent, high-quality angiograms (score = 2.6 ± 0.2, SBR = 7.4 ± 0.2) but minimal rim enhancement (score = 0.3 ± 0.2). Albumin-(Gd-DTPA)30 combined with high-resolution MR imaging produces time-persistent, detailed angiographic definition of peritumoral vessels. Vascular maps obtained with gadopentetate dimeglumine enhancement are not time persistent or of equal quality." @default.
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• W1971234495 date "1995-10-01" @default.
• W1971234495 modified "2023-09-25" @default.
• W1971234495 title "Tumor angiography using high-resolution, three-dimensional magnetic resonance imaging: Comparison of gadopentetate dimeglumine and a macromolecular blood-pool contrast agent" @default.
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• W1971234495 doi "https://doi.org/10.1016/s1076-6332(05)80059-5" @default.
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