FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971244299> ?p ?o ?g. }

• W1971244299 abstract "Hydrogen sulfide (H(2)S) is now recognized as an important signaling molecule and has been shown to have vasodilator and cardio-protectant effects. More recently it has been suggested that H(2)S may also act within the brain to reduce blood pressure (BP). In the present study we have demonstrated the presence of the H(2)S-producing enzyme, cystathionine-β-synthase (CBS) in the rostral ventrolateral medulla (RVLM), and the hypothalamic paraventricular nucleus (PVN), brain regions with key cardiovascular regulatory functions. The cardiovascular role of H(2)S was investigated by determining the BP, heart rate (HR), and lumbar sympathetic nerve activity (LSNA) responses elicited by a H(2)S donor sodium hydrogen sulfide (NaHS) or inhibitors of CBS, microinjected into the RVLM and PVN. In anesthetized Wistar Kyoto rats bilateral microinjections of NaHS (0.2-2000 pmol/side) into the RVLM did not significantly affect BP, HR, or LSNA, compared to vehicle. Similarly, when the CBS inhibitors, amino-oxyacetate (AOA; 0.1-1.0 nmol/side) or hydroxylamine (HA; 0.2-2.0 nmol/side), were administered into the RVLM, there were no significant effects on the cardiovascular variables compared to vehicle. Microinjections into the PVN of NaHS, HA, and AOA had no consistent significant effects on BP, HR, or LSNA compared to vehicle. We also investigated the cardiovascular responses to NaHS microinjected into the RVLM and PVN in spontaneously hypertensive rats. Again, there were no significant effects on BP, HR, and LSNA. Together, these results suggest that H(2)S in the RVLM and PVN does not have a major role in cardiovascular regulation." @default.
• W1971244299 created "2016-06-24" @default.
• W1971244299 creator A5004748143 @default.
• W1971244299 creator A5037648074 @default.
• W1971244299 creator A5071993036 @default.
• W1971244299 creator A5084787797 @default.
• W1971244299 date "2011-01-01" @default.
• W1971244299 modified "2023-09-27" @default.
• W1971244299 title "Hydrogen Sulfide in the RVLM and PVN has No Effect on Cardiovascular Regulation" @default.
• W1971244299 cites W1964527234 @default.
• W1971244299 cites W1966409424 @default.
• W1971244299 cites W1975072795 @default.
• W1971244299 cites W1976599798 @default.
• W1971244299 cites W1976626577 @default.
• W1971244299 cites W1987639801 @default.
• W1971244299 cites W1991930915 @default.
• W1971244299 cites W2000610689 @default.
• W1971244299 cites W2002360764 @default.
• W1971244299 cites W2003976073 @default.
• W1971244299 cites W2014595652 @default.
• W1971244299 cites W2014641242 @default.
• W1971244299 cites W2015407072 @default.
• W1971244299 cites W2017161829 @default.
• W1971244299 cites W2019904078 @default.
• W1971244299 cites W2022243364 @default.
• W1971244299 cites W2030241661 @default.
• W1971244299 cites W2048555372 @default.
• W1971244299 cites W2051003302 @default.
• W1971244299 cites W2054064167 @default.
• W1971244299 cites W2068065773 @default.
• W1971244299 cites W2072474837 @default.
• W1971244299 cites W2080766203 @default.
• W1971244299 cites W2083873732 @default.
• W1971244299 cites W2086951343 @default.
• W1971244299 cites W2106521380 @default.
• W1971244299 cites W2107312159 @default.
• W1971244299 cites W2117579668 @default.
• W1971244299 cites W2124936046 @default.
• W1971244299 cites W2126605729 @default.
• W1971244299 cites W2132307929 @default.
• W1971244299 cites W2141610173 @default.
• W1971244299 cites W2148336465 @default.
• W1971244299 cites W2166439489 @default.
• W1971244299 cites W2381806856 @default.
• W1971244299 cites W39489114 @default.
• W1971244299 doi "https://doi.org/10.3389/fphys.2011.00055" @default.
• W1971244299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3171070" @default.
• W1971244299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21941511" @default.
• W1971244299 hasPublicationYear "2011" @default.
• W1971244299 type Work @default.
• W1971244299 sameAs 1971244299 @default.
• W1971244299 citedByCount "14" @default.
• W1971244299 countsByYear W19712442992012 @default.
• W1971244299 countsByYear W19712442992014 @default.
• W1971244299 countsByYear W19712442992015 @default.
• W1971244299 countsByYear W19712442992017 @default.
• W1971244299 countsByYear W19712442992018 @default.
• W1971244299 countsByYear W19712442992021 @default.
• W1971244299 countsByYear W19712442992022 @default.
• W1971244299 countsByYear W19712442992023 @default.
• W1971244299 crossrefType "journal-article" @default.
• W1971244299 hasAuthorship W1971244299A5004748143 @default.
• W1971244299 hasAuthorship W1971244299A5037648074 @default.
• W1971244299 hasAuthorship W1971244299A5071993036 @default.
• W1971244299 hasAuthorship W1971244299A5084787797 @default.
• W1971244299 hasBestOaLocation W19712442991 @default.
• W1971244299 hasConcept C126322002 @default.
• W1971244299 hasConcept C134018914 @default.
• W1971244299 hasConcept C178790620 @default.
• W1971244299 hasConcept C185592680 @default.
• W1971244299 hasConcept C2778110749 @default.
• W1971244299 hasConcept C2780519940 @default.
• W1971244299 hasConcept C2780564542 @default.
• W1971244299 hasConcept C33114225 @default.
• W1971244299 hasConcept C518881349 @default.
• W1971244299 hasConcept C529278444 @default.
• W1971244299 hasConcept C71924100 @default.
• W1971244299 hasConceptScore W1971244299C126322002 @default.
• W1971244299 hasConceptScore W1971244299C134018914 @default.
• W1971244299 hasConceptScore W1971244299C178790620 @default.
• W1971244299 hasConceptScore W1971244299C185592680 @default.
• W1971244299 hasConceptScore W1971244299C2778110749 @default.
• W1971244299 hasConceptScore W1971244299C2780519940 @default.
• W1971244299 hasConceptScore W1971244299C2780564542 @default.
• W1971244299 hasConceptScore W1971244299C33114225 @default.
• W1971244299 hasConceptScore W1971244299C518881349 @default.
• W1971244299 hasConceptScore W1971244299C529278444 @default.
• W1971244299 hasConceptScore W1971244299C71924100 @default.
• W1971244299 hasLocation W19712442991 @default.
• W1971244299 hasLocation W19712442992 @default.
• W1971244299 hasLocation W19712442993 @default.
• W1971244299 hasLocation W19712442994 @default.
• W1971244299 hasLocation W19712442995 @default.
• W1971244299 hasOpenAccess W1971244299 @default.
• W1971244299 hasPrimaryLocation W19712442991 @default.
• W1971244299 hasRelatedWork W1971244299 @default.
• W1971244299 hasRelatedWork W1979139803 @default.
• W1971244299 hasRelatedWork W1980399151 @default.
• W1971244299 hasRelatedWork W1996475372 @default.
• W1971244299 hasRelatedWork W2011380907 @default.

• next