FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971248612> ?p ?o ?g. }

• W1971248612 endingPage "2212" @default.
• W1971248612 startingPage "2207" @default.
• W1971248612 abstract "Activating point mutations in the phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) are among the most common molecular defects in invasive breast cancer. Point mutations in the downstream kinase AKT1 are seen in a minority of carcinomas. These mutations are found preferentially in estrogen receptor–positive and Her2-positive breast carcinomas; however, special morphologic types of breast cancer have not been well studied. Twenty-nine cases of pure invasive mucinous carcinoma and 9 cases of ductal carcinoma with mucinous differentiation were screened for a panel of point mutations (>321 mutations in 30 genes) using a multiplex polymerase chain reaction panel with mass spectroscopy readout. In addition, associated ductal carcinoma in situ, hyperplasia, or columnar cell lesions were separately tested where available (25 lesions). In 3 invasive cases and 15 ductal carcinoma in situ/proliferative lesions, PIK3CA hotspot mutations were, instead, tested by direct sequencing. No point mutations were identified in invasive mucinous breast carcinoma. This contrasts with the 35% frequency of PIK3CA mutations in a comparative group of invasive ductal carcinomas of no special type. Interestingly, PIK3CA hotspot point mutations were identified in associated ductal carcinoma in situ (3/14) and hyperplasia (atypical ductal hyperplasia [2/3], usual ductal hyperplasia [2/3], columnar cell change [1/5]), suggesting that PIK3CA mutations may play a role in breast epithelial proliferation. This series represents the largest study, to date, of PIK3CA genotyping in mucinous carcinoma and supports the unique pathogenetics of invasive mucinous breast carcinoma." @default.
• W1971248612 created "2016-06-24" @default.
• W1971248612 creator A5007688998 @default.
• W1971248612 creator A5017363745 @default.
• W1971248612 creator A5020561263 @default.
• W1971248612 creator A5026593581 @default.
• W1971248612 creator A5035890697 @default.
• W1971248612 creator A5061310592 @default.
• W1971248612 creator A5071485060 @default.
• W1971248612 creator A5073227672 @default.
• W1971248612 creator A5079126831 @default.
• W1971248612 creator A5080829251 @default.
• W1971248612 date "2012-12-01" @default.
• W1971248612 modified "2023-09-27" @default.
• W1971248612 title "Mucinous breast carcinomas lack PIK3CA and AKT1 mutations" @default.
• W1971248612 cites W1913085465 @default.
• W1971248612 cites W1965330738 @default.
• W1971248612 cites W1967570571 @default.
• W1971248612 cites W1971843650 @default.
• W1971248612 cites W1977267072 @default.
• W1971248612 cites W1994703138 @default.
• W1971248612 cites W1996872884 @default.
• W1971248612 cites W1997890450 @default.
• W1971248612 cites W2007496769 @default.
• W1971248612 cites W2010432825 @default.
• W1971248612 cites W2013831759 @default.
• W1971248612 cites W2018023891 @default.
• W1971248612 cites W2043666769 @default.
• W1971248612 cites W2063550022 @default.
• W1971248612 cites W2078358665 @default.
• W1971248612 cites W2092153901 @default.
• W1971248612 cites W2106036365 @default.
• W1971248612 cites W2110578052 @default.
• W1971248612 cites W2144957807 @default.
• W1971248612 cites W2152070942 @default.
• W1971248612 cites W2154692501 @default.
• W1971248612 cites W2160928966 @default.
• W1971248612 cites W2167185450 @default.
• W1971248612 cites W2311060994 @default.
• W1971248612 cites W4376567028 @default.
• W1971248612 doi "https://doi.org/10.1016/j.humpath.2012.03.012" @default.
• W1971248612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22705004" @default.
• W1971248612 hasPublicationYear "2012" @default.
• W1971248612 type Work @default.
• W1971248612 sameAs 1971248612 @default.
• W1971248612 citedByCount "35" @default.
• W1971248612 countsByYear W19712486122012 @default.
• W1971248612 countsByYear W19712486122013 @default.
• W1971248612 countsByYear W19712486122014 @default.
• W1971248612 countsByYear W19712486122015 @default.
• W1971248612 countsByYear W19712486122016 @default.
• W1971248612 countsByYear W19712486122017 @default.
• W1971248612 countsByYear W19712486122018 @default.
• W1971248612 countsByYear W19712486122019 @default.
• W1971248612 countsByYear W19712486122020 @default.
• W1971248612 countsByYear W19712486122021 @default.
• W1971248612 countsByYear W19712486122022 @default.
• W1971248612 countsByYear W19712486122023 @default.
• W1971248612 crossrefType "journal-article" @default.
• W1971248612 hasAuthorship W1971248612A5007688998 @default.
• W1971248612 hasAuthorship W1971248612A5017363745 @default.
• W1971248612 hasAuthorship W1971248612A5020561263 @default.
• W1971248612 hasAuthorship W1971248612A5026593581 @default.
• W1971248612 hasAuthorship W1971248612A5035890697 @default.
• W1971248612 hasAuthorship W1971248612A5061310592 @default.
• W1971248612 hasAuthorship W1971248612A5071485060 @default.
• W1971248612 hasAuthorship W1971248612A5073227672 @default.
• W1971248612 hasAuthorship W1971248612A5079126831 @default.
• W1971248612 hasAuthorship W1971248612A5080829251 @default.
• W1971248612 hasConcept C104317684 @default.
• W1971248612 hasConcept C121608353 @default.
• W1971248612 hasConcept C126322002 @default.
• W1971248612 hasConcept C142724271 @default.
• W1971248612 hasConcept C176944494 @default.
• W1971248612 hasConcept C2777546739 @default.
• W1971248612 hasConcept C2777562237 @default.
• W1971248612 hasConcept C2777874381 @default.
• W1971248612 hasConcept C2780862961 @default.
• W1971248612 hasConcept C2781182431 @default.
• W1971248612 hasConcept C501734568 @default.
• W1971248612 hasConcept C502942594 @default.
• W1971248612 hasConcept C530470458 @default.
• W1971248612 hasConcept C54355233 @default.
• W1971248612 hasConcept C71924100 @default.
• W1971248612 hasConcept C86803240 @default.
• W1971248612 hasConceptScore W1971248612C104317684 @default.
• W1971248612 hasConceptScore W1971248612C121608353 @default.
• W1971248612 hasConceptScore W1971248612C126322002 @default.
• W1971248612 hasConceptScore W1971248612C142724271 @default.
• W1971248612 hasConceptScore W1971248612C176944494 @default.
• W1971248612 hasConceptScore W1971248612C2777546739 @default.
• W1971248612 hasConceptScore W1971248612C2777562237 @default.
• W1971248612 hasConceptScore W1971248612C2777874381 @default.
• W1971248612 hasConceptScore W1971248612C2780862961 @default.
• W1971248612 hasConceptScore W1971248612C2781182431 @default.
• W1971248612 hasConceptScore W1971248612C501734568 @default.
• W1971248612 hasConceptScore W1971248612C502942594 @default.
• W1971248612 hasConceptScore W1971248612C530470458 @default.

• next