Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971250615> ?p ?o ?g. }
- W1971250615 endingPage "905" @default.
- W1971250615 startingPage "900" @default.
- W1971250615 abstract "Abstract Multiple evidence suggests an involvement of the dopamine neurotransmitter system in Tourette syndrome (TS). Therefore, dopaminergic candidate genes are in the center of genetic association analyses of TS. In this study, 103 TS patients and their parents have been characterized for different dopamine‐related polymorphisms including the 48 bp variable number of tandem repeats (VNTR) of the dopamine D4 receptor (DRD4) gene, the 40 bp VNTR of the dopamine transporter (DAT1, SLC6A3) gene and the Val158Met polymorphism of the catechol‐O‐methyltransferase (COMT) gene. In addition, the 120 bp duplication and three single nucleotide polymorphisms (SNPs) were assessed in the promoter region of the DRD4 gene. The −616G allele and the 2‐G‐A‐C haplotype (i.e., the 2‐repeat form of the 120 bp sequence ∼ −616G ∼ −615A ∼ −521C combination) were preferentially transmitted, however, these results did not remain significant after correction for multiple testing. Case‐control analyses have also been carried out, resulting in negative findings. On the other hand, using a dimensional approach, the DAT1 40 bp VNTR showed an association with the peak tic‐severity as measured by the Yale Global Tic Severity Scale. Patients with at least one copy of the 9‐repeat allele had significantly more severe symptoms than individuals with the homozygous 10/10 genotype ( P = 0.002). In summary, allele frequencies did not differ between cases and controls, but DAT1 genotype accounted for variations of tic severity within the TS group. © 2007 Wiley‐Liss, Inc." @default.
- W1971250615 created "2016-06-24" @default.
- W1971250615 creator A5022807126 @default.
- W1971250615 creator A5032171654 @default.
- W1971250615 creator A5042457998 @default.
- W1971250615 creator A5056993307 @default.
- W1971250615 creator A5061973020 @default.
- W1971250615 creator A5071936399 @default.
- W1971250615 creator A5089008140 @default.
- W1971250615 date "2007-05-16" @default.
- W1971250615 modified "2023-10-16" @default.
- W1971250615 title "Dopaminergic candidate genes in Tourette syndrome: Association between tic severity and 3′ UTR polymorphism of the dopamine transporter gene" @default.
- W1971250615 cites W1518679907 @default.
- W1971250615 cites W1964141250 @default.
- W1971250615 cites W1974978981 @default.
- W1971250615 cites W1986983811 @default.
- W1971250615 cites W2004574418 @default.
- W1971250615 cites W2010604180 @default.
- W1971250615 cites W2012285125 @default.
- W1971250615 cites W2012866540 @default.
- W1971250615 cites W2015114132 @default.
- W1971250615 cites W2019101336 @default.
- W1971250615 cites W2031134758 @default.
- W1971250615 cites W2038444868 @default.
- W1971250615 cites W2041405722 @default.
- W1971250615 cites W2053187997 @default.
- W1971250615 cites W2059251696 @default.
- W1971250615 cites W2067094774 @default.
- W1971250615 cites W2080845329 @default.
- W1971250615 cites W2083944558 @default.
- W1971250615 cites W2084721522 @default.
- W1971250615 cites W2092140193 @default.
- W1971250615 cites W2092868760 @default.
- W1971250615 cites W2098030978 @default.
- W1971250615 cites W2100040984 @default.
- W1971250615 cites W2105293054 @default.
- W1971250615 cites W2110395878 @default.
- W1971250615 cites W2120835114 @default.
- W1971250615 cites W2133543996 @default.
- W1971250615 cites W2138038505 @default.
- W1971250615 cites W2156989422 @default.
- W1971250615 cites W2162486797 @default.
- W1971250615 cites W2169416578 @default.
- W1971250615 cites W2335607448 @default.
- W1971250615 cites W296252275 @default.
- W1971250615 cites W51032589 @default.
- W1971250615 doi "https://doi.org/10.1002/ajmg.b.30517" @default.
- W1971250615 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17508355" @default.
- W1971250615 hasPublicationYear "2007" @default.
- W1971250615 type Work @default.
- W1971250615 sameAs 1971250615 @default.
- W1971250615 citedByCount "60" @default.
- W1971250615 countsByYear W19712506152012 @default.
- W1971250615 countsByYear W19712506152013 @default.
- W1971250615 countsByYear W19712506152014 @default.
- W1971250615 countsByYear W19712506152015 @default.
- W1971250615 countsByYear W19712506152016 @default.
- W1971250615 countsByYear W19712506152017 @default.
- W1971250615 countsByYear W19712506152018 @default.
- W1971250615 countsByYear W19712506152019 @default.
- W1971250615 countsByYear W19712506152020 @default.
- W1971250615 countsByYear W19712506152021 @default.
- W1971250615 countsByYear W19712506152022 @default.
- W1971250615 countsByYear W19712506152023 @default.
- W1971250615 crossrefType "journal-article" @default.
- W1971250615 hasAuthorship W1971250615A5022807126 @default.
- W1971250615 hasAuthorship W1971250615A5032171654 @default.
- W1971250615 hasAuthorship W1971250615A5042457998 @default.
- W1971250615 hasAuthorship W1971250615A5056993307 @default.
- W1971250615 hasAuthorship W1971250615A5061973020 @default.
- W1971250615 hasAuthorship W1971250615A5071936399 @default.
- W1971250615 hasAuthorship W1971250615A5089008140 @default.
- W1971250615 hasConcept C104317684 @default.
- W1971250615 hasConcept C118552586 @default.
- W1971250615 hasConcept C134018914 @default.
- W1971250615 hasConcept C135763542 @default.
- W1971250615 hasConcept C137183658 @default.
- W1971250615 hasConcept C149737253 @default.
- W1971250615 hasConcept C153209595 @default.
- W1971250615 hasConcept C180754005 @default.
- W1971250615 hasConcept C189036908 @default.
- W1971250615 hasConcept C197754878 @default.
- W1971250615 hasConcept C2776755682 @default.
- W1971250615 hasConcept C2777026814 @default.
- W1971250615 hasConcept C513476851 @default.
- W1971250615 hasConcept C54355233 @default.
- W1971250615 hasConcept C69991583 @default.
- W1971250615 hasConcept C71924100 @default.
- W1971250615 hasConcept C86803240 @default.
- W1971250615 hasConceptScore W1971250615C104317684 @default.
- W1971250615 hasConceptScore W1971250615C118552586 @default.
- W1971250615 hasConceptScore W1971250615C134018914 @default.
- W1971250615 hasConceptScore W1971250615C135763542 @default.
- W1971250615 hasConceptScore W1971250615C137183658 @default.
- W1971250615 hasConceptScore W1971250615C149737253 @default.
- W1971250615 hasConceptScore W1971250615C153209595 @default.
- W1971250615 hasConceptScore W1971250615C180754005 @default.
- W1971250615 hasConceptScore W1971250615C189036908 @default.