FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971251355> ?p ?o ?g. }

• W1971251355 endingPage "152" @default.
• W1971251355 startingPage "147" @default.
• W1971251355 abstract "We have previously reported that the buccal mucosa can support delayed type hypersensitivity (DTH) reactions to contact sensitizers. In the present study, we show that cells isolated from the buccal epithelium are able to present soluble exogenous antigens to specific T cells. Single cell suspensions obtained by enzymatic dispersion of buccal epithelial sheets could present the native protein antigen hen-egg lysozyme (HEL) to the I-Ak-restricted CD4+ T-cell hybridoma specific for a.a 46-61 on HEL. T-cell activation resulted in interleukin-2 (IL-2) production which could be inhibited by anti-major histocompatibility complex (MHC) class-II antibodies of pertinent specificity. Immunohistochemical staining of whole buccal epithelial sheets revealed that all MHC II positive cells had a dendritic morphology and expressed ATPase activity, indicating that these cells represent a major antigen-presenting cell (APC) population in this tissue. Furthermore, single cell suspensions isolated from buccal epithelium (BEC) after local in vivo administration of either a native soluble protein, a synthetic dodecapeptide, or a contact sensitizer were able to activate antigen-specific T cells ex vivo. Kinetic analyses indicated that maximal APC activity in the oral epithelium occurred within 1 hr after local antigen administration, and had essentially vanished after 24 hr. Conversely, APC activity was undetectable in draining cervico-mandibular lymph node cell suspensions recovered 1 hr after local antigen injection but became manifest after 3-24 hr. These observations suggest that dendritic cells can acquire antigens in the buccal epithelium and migrate to draining lymph nodes where they present processed antigen to MHC class II-restricted T cells. This APC population may thus be a critical element in the initiation of Th1-driven DTH responses in the oral mucosa." @default.
• W1971251355 created "2016-06-24" @default.
• W1971251355 creator A5003406476 @default.
• W1971251355 creator A5011708446 @default.
• W1971251355 creator A5052490861 @default.
• W1971251355 creator A5066578927 @default.
• W1971251355 creator A5091546251 @default.
• W1971251355 date "1996-05-01" @default.
• W1971251355 modified "2023-10-16" @default.
• W1971251355 title "<b>Antigen presentation in the murine oral epithelium</b>" @default.
• W1971251355 cites W1521286109 @default.
• W1971251355 cites W1565243386 @default.
• W1971251355 cites W17023053 @default.
• W1971251355 cites W1853022482 @default.
• W1971251355 cites W1975388425 @default.
• W1971251355 cites W1980641871 @default.
• W1971251355 cites W2010350911 @default.
• W1971251355 cites W2024164044 @default.
• W1971251355 cites W2029062375 @default.
• W1971251355 cites W2075025882 @default.
• W1971251355 cites W2082590314 @default.
• W1971251355 cites W2092095871 @default.
• W1971251355 cites W2095818050 @default.
• W1971251355 cites W2096152012 @default.
• W1971251355 cites W2097682908 @default.
• W1971251355 cites W2101186488 @default.
• W1971251355 cites W2116314108 @default.
• W1971251355 cites W2123223407 @default.
• W1971251355 cites W2132552157 @default.
• W1971251355 cites W2177327503 @default.
• W1971251355 cites W2411028702 @default.
• W1971251355 doi "https://doi.org/10.1046/j.1365-2567.1996.d01-647.x" @default.
• W1971251355 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1456467" @default.
• W1971251355 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8707342" @default.
• W1971251355 hasPublicationYear "1996" @default.
• W1971251355 type Work @default.
• W1971251355 sameAs 1971251355 @default.
• W1971251355 citedByCount "42" @default.
• W1971251355 countsByYear W19712513552012 @default.
• W1971251355 countsByYear W19712513552013 @default.
• W1971251355 countsByYear W19712513552014 @default.
• W1971251355 countsByYear W19712513552017 @default.
• W1971251355 countsByYear W19712513552020 @default.
• W1971251355 crossrefType "journal-article" @default.
• W1971251355 hasAuthorship W1971251355A5003406476 @default.
• W1971251355 hasAuthorship W1971251355A5011708446 @default.
• W1971251355 hasAuthorship W1971251355A5052490861 @default.
• W1971251355 hasAuthorship W1971251355A5066578927 @default.
• W1971251355 hasAuthorship W1971251355A5091546251 @default.
• W1971251355 hasBestOaLocation W19712513552 @default.
• W1971251355 hasConcept C147483822 @default.
• W1971251355 hasConcept C153911025 @default.
• W1971251355 hasConcept C159654299 @default.
• W1971251355 hasConcept C195735259 @default.
• W1971251355 hasConcept C203014093 @default.
• W1971251355 hasConcept C207936829 @default.
• W1971251355 hasConcept C2776090121 @default.
• W1971251355 hasConcept C2908647359 @default.
• W1971251355 hasConcept C529295009 @default.
• W1971251355 hasConcept C54355233 @default.
• W1971251355 hasConcept C67662055 @default.
• W1971251355 hasConcept C71924100 @default.
• W1971251355 hasConcept C83464605 @default.
• W1971251355 hasConcept C86803240 @default.
• W1971251355 hasConcept C8891405 @default.
• W1971251355 hasConcept C98274493 @default.
• W1971251355 hasConcept C99454951 @default.
• W1971251355 hasConceptScore W1971251355C147483822 @default.
• W1971251355 hasConceptScore W1971251355C153911025 @default.
• W1971251355 hasConceptScore W1971251355C159654299 @default.
• W1971251355 hasConceptScore W1971251355C195735259 @default.
• W1971251355 hasConceptScore W1971251355C203014093 @default.
• W1971251355 hasConceptScore W1971251355C207936829 @default.
• W1971251355 hasConceptScore W1971251355C2776090121 @default.
• W1971251355 hasConceptScore W1971251355C2908647359 @default.
• W1971251355 hasConceptScore W1971251355C529295009 @default.
• W1971251355 hasConceptScore W1971251355C54355233 @default.
• W1971251355 hasConceptScore W1971251355C67662055 @default.
• W1971251355 hasConceptScore W1971251355C71924100 @default.
• W1971251355 hasConceptScore W1971251355C83464605 @default.
• W1971251355 hasConceptScore W1971251355C86803240 @default.
• W1971251355 hasConceptScore W1971251355C8891405 @default.
• W1971251355 hasConceptScore W1971251355C98274493 @default.
• W1971251355 hasConceptScore W1971251355C99454951 @default.
• W1971251355 hasIssue "1" @default.
• W1971251355 hasLocation W19712513551 @default.
• W1971251355 hasLocation W19712513552 @default.
• W1971251355 hasLocation W19712513553 @default.
• W1971251355 hasOpenAccess W1971251355 @default.
• W1971251355 hasPrimaryLocation W19712513551 @default.
• W1971251355 hasRelatedWork W1661038996 @default.
• W1971251355 hasRelatedWork W1680198589 @default.
• W1971251355 hasRelatedWork W1970251634 @default.
• W1971251355 hasRelatedWork W2000941383 @default.
• W1971251355 hasRelatedWork W2028370002 @default.
• W1971251355 hasRelatedWork W2084632240 @default.
• W1971251355 hasRelatedWork W2094482300 @default.
• W1971251355 hasRelatedWork W2403733398 @default.

• next