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- W1971257060 abstract "In Reply.— Povidone-iodine solution is an effective agent on normal skin. However, it is not a very effective antiseptic agent in full-thickness wounds. 1 The usual explanation given for povidone-iodine solution's ineffectiveness in full-thickness wounds is that wounds, unlike normal skin, contain wound fluids. The wound's fluid proteins bind iodine, the active agent in povidone-iodine solution, and thereby reduce the solution's effectiveness. 2 An alternative explanation for the lack of effect in full-thickness wounds might be that the wound fluids provide the bacteria a protective coating. 3 The latter possibility has been proposed to explain the ability of Pseudomonas cepacia to survive in povidone-iodine solution. Regardless of the mechanisms of the inactivity of povidone-iodine in deep wounds, our findings in superficial wounds are not surprising. As Dr Leyden points out, we used only one application of a small volume of povidone-iodine into a shallow wound containing large numbers of" @default.
- W1971257060 created "2016-06-24" @default.
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- W1971257060 date "1984-11-01" @default.
- W1971257060 modified "2023-09-26" @default.
- W1971257060 title "Topical Antiseptics-Reply" @default.
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- W1971257060 doi "https://doi.org/10.1001/archderm.1984.01650470025007" @default.
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