Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971260572> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1971260572 abstract "DNA is a long flexible polymer and is involved in several fundamental cellular processes such as transcription, replication and chromosome packaging. These processes induce forces and torques in the DNA which deform it. These deformations in turn affect the structure and function of DNA. However, understanding of the dynamic response of DNA to the various forces that act on it is still far from complete. Several experiments have been carried out to study these responses most of which use a micron sized magnetic bead attached to the DNA molecule to both manipulate it and to observe its dynamics. One limitation of this approach is that the dynamics of the DNA molecule has mostly been characterized “indirectly” by observing the dynamics of the magnetic bead. It is also reasonable to expect that, because of the size of the bead relative to that of the DNA, the magnetic bead dynamics will obscure that of the DNA. We adapt existing coarse-grained Brownian dynamics models of DNA to develop a model capable of representing the dynamics of DNA without any of the artifacts inherent to the experiments. This model accounts for bending, torsion, extension, electrostatics, hydrodynamics and the random thermal forces acting on DNA in an electrolyte solution. We then carry out Brownian dynamics simulations with our model to benchmark with well established theoretical results of a stretched polymer in solution. Finally, we employ our model to predict the relaxation time scale for single molecule experiments which sets the framework for future studies in which we plan to further shed light on the dynamics of DNA over long length and time scales." @default.
- W1971260572 created "2016-06-24" @default.
- W1971260572 creator A5026586010 @default.
- W1971260572 creator A5059261908 @default.
- W1971260572 date "2014-08-17" @default.
- W1971260572 modified "2023-10-16" @default.
- W1971260572 title "Brownian Dynamics Simulation of the Dynamics of Stretched DNA" @default.
- W1971260572 cites W1976539937 @default.
- W1971260572 cites W1980271112 @default.
- W1971260572 cites W2014901554 @default.
- W1971260572 cites W2023269994 @default.
- W1971260572 cites W2024316435 @default.
- W1971260572 cites W2049279004 @default.
- W1971260572 cites W2052254741 @default.
- W1971260572 cites W2060758841 @default.
- W1971260572 cites W2066101808 @default.
- W1971260572 cites W2070557033 @default.
- W1971260572 cites W2073747644 @default.
- W1971260572 cites W2102698033 @default.
- W1971260572 cites W2110992704 @default.
- W1971260572 cites W2120898812 @default.
- W1971260572 cites W2126466006 @default.
- W1971260572 cites W2130038116 @default.
- W1971260572 doi "https://doi.org/10.1115/detc2014-35487" @default.
- W1971260572 hasPublicationYear "2014" @default.
- W1971260572 type Work @default.
- W1971260572 sameAs 1971260572 @default.
- W1971260572 citedByCount "2" @default.
- W1971260572 countsByYear W19712605722016 @default.
- W1971260572 crossrefType "proceedings-article" @default.
- W1971260572 hasAuthorship W1971260572A5026586010 @default.
- W1971260572 hasAuthorship W1971260572A5059261908 @default.
- W1971260572 hasConcept C105480513 @default.
- W1971260572 hasConcept C112401455 @default.
- W1971260572 hasConcept C117626034 @default.
- W1971260572 hasConcept C121332964 @default.
- W1971260572 hasConcept C121864883 @default.
- W1971260572 hasConcept C130603088 @default.
- W1971260572 hasConcept C145912823 @default.
- W1971260572 hasConcept C185592680 @default.
- W1971260572 hasConcept C186060115 @default.
- W1971260572 hasConcept C24890656 @default.
- W1971260572 hasConcept C552990157 @default.
- W1971260572 hasConcept C55493867 @default.
- W1971260572 hasConcept C5637370 @default.
- W1971260572 hasConcept C62520636 @default.
- W1971260572 hasConcept C74650414 @default.
- W1971260572 hasConcept C86803240 @default.
- W1971260572 hasConceptScore W1971260572C105480513 @default.
- W1971260572 hasConceptScore W1971260572C112401455 @default.
- W1971260572 hasConceptScore W1971260572C117626034 @default.
- W1971260572 hasConceptScore W1971260572C121332964 @default.
- W1971260572 hasConceptScore W1971260572C121864883 @default.
- W1971260572 hasConceptScore W1971260572C130603088 @default.
- W1971260572 hasConceptScore W1971260572C145912823 @default.
- W1971260572 hasConceptScore W1971260572C185592680 @default.
- W1971260572 hasConceptScore W1971260572C186060115 @default.
- W1971260572 hasConceptScore W1971260572C24890656 @default.
- W1971260572 hasConceptScore W1971260572C552990157 @default.
- W1971260572 hasConceptScore W1971260572C55493867 @default.
- W1971260572 hasConceptScore W1971260572C5637370 @default.
- W1971260572 hasConceptScore W1971260572C62520636 @default.
- W1971260572 hasConceptScore W1971260572C74650414 @default.
- W1971260572 hasConceptScore W1971260572C86803240 @default.
- W1971260572 hasLocation W19712605721 @default.
- W1971260572 hasOpenAccess W1971260572 @default.
- W1971260572 hasPrimaryLocation W19712605721 @default.
- W1971260572 hasRelatedWork W1525016149 @default.
- W1971260572 hasRelatedWork W185949442 @default.
- W1971260572 hasRelatedWork W1993007435 @default.
- W1971260572 hasRelatedWork W2000411307 @default.
- W1971260572 hasRelatedWork W2016307290 @default.
- W1971260572 hasRelatedWork W2025808724 @default.
- W1971260572 hasRelatedWork W2056949406 @default.
- W1971260572 hasRelatedWork W2068386280 @default.
- W1971260572 hasRelatedWork W2084868118 @default.
- W1971260572 hasRelatedWork W2097057475 @default.
- W1971260572 hasRelatedWork W2098066911 @default.
- W1971260572 hasRelatedWork W2105727817 @default.
- W1971260572 hasRelatedWork W2158655795 @default.
- W1971260572 hasRelatedWork W2585382081 @default.
- W1971260572 hasRelatedWork W2590234346 @default.
- W1971260572 hasRelatedWork W2942345489 @default.
- W1971260572 hasRelatedWork W3048853199 @default.
- W1971260572 hasRelatedWork W3100733988 @default.
- W1971260572 hasRelatedWork W3101529125 @default.
- W1971260572 hasRelatedWork W3170241801 @default.
- W1971260572 isParatext "false" @default.
- W1971260572 isRetracted "false" @default.
- W1971260572 magId "1971260572" @default.
- W1971260572 workType "article" @default.