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• W1971285808 abstract "Abstract The disialoganglioside G D3 is an oncofetal marker of a variety of human tumors including melanoma and neuroblastoma, playing a key role in tumor progression. G D3 and 9- O -acetyl-G D3 are overexpressed in approximately 50% of invasive ductal breast carcinoma, but no relationship has been established between disialoganglioside expression and breast cancer progression. In order to determine the effect of G D3 expression on breast cancer development, we analyzed the biosynthesis of gangliosides in several breast epithelial cell lines including MDA-MB-231, MCF-7, BT-20, T47-D, and MCF10A, by immunocytochemistry, flow cytometry, and real-time PCR. Our results show that, in comparison to tumors, cultured breast cancer cells express a limited pattern of gangliosides. Disialogangliosides were not detected in any cell line and G M3 was only observed at the cell surface of MDA-MB-231 cells. To evaluate the influence of G D3 in breast cancer cell behavior, we established and characterized MDA-MB-231 cells overexpressing G D3 synthase. We show that G D3 synthase expressing cells accumulate G D3 , G D2 , and G T3 at the cell surface. Moreover, G D3 synthase overexpression bypasses the need of serum for cell growth and increases cell migration. This suggests that G D3 synthase overexpression may contribute to increasing the malignant properties of breast cancer cells." @default.
• W1971285808 created "2016-06-24" @default.
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• W1971285808 date "2009-03-31" @default.
• W1971285808 modified "2023-09-26" @default.
• W1971285808 title "G_D3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells" @default.
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• W1971285808 doi "https://doi.org/10.1515/bc.2009.054" @default.
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