Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971287979> ?p ?o ?g. }
- W1971287979 endingPage "1638" @default.
- W1971287979 startingPage "1633" @default.
- W1971287979 abstract "Depigmentation of the substantia nigra is a conspicuous pathological feature of Parkinson's disease and related to a loss of neuromelanin. Similar to melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1-weighted magnetic resonance imaging. The aim of this study was to assess signal changes in the substantia nigra in patients with Parkinson's disease using an optimized neuromelanin-sensitive T1 scan. Ten patients with Parkinson's disease and 12 matched controls underwent high-resolution T1-weighted magnetic resonance imaging with magnetization transfer effect at 3T. The size and signal intensity of the substantia nigra pars compacta were determined as the number of pixels with signal intensity higher than background signal intensity + 3 standard deviations and regional contrast ratio. Patients were subclassified as early stage (n = 6) and late stage (n = 4) using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Parkinson's disease staging scale. The T1 hyperintense area in the substantia nigra was substantially smaller in patients compared with controls (−60%, P < .01), and contrast was reduced (−3%, P < .05). Size reduction was even more pronounced in more advanced disease (−78%) than in early-stage disease (−47%). We present preliminary findings using a modified T1-weighted magnetic resonance imaging technique showing stage-dependent substantia nigra signal reduction in Parkinson's disease as a putative marker of neuromelanin loss. Our data suggest that reduction in the size of neuromelanin-rich substantia nigra correlates well with postmortem observations of dopaminergic neuron loss. Further validation of our results could potentially lead to development of a new biomarker of disease progression in Parkinson's disease. © 2011 Movement Disorder Society" @default.
- W1971287979 created "2016-06-24" @default.
- W1971287979 creator A5007912600 @default.
- W1971287979 creator A5025188319 @default.
- W1971287979 creator A5072684321 @default.
- W1971287979 creator A5076384706 @default.
- W1971287979 creator A5077230679 @default.
- W1971287979 creator A5078023911 @default.
- W1971287979 date "2011-04-12" @default.
- W1971287979 modified "2023-10-11" @default.
- W1971287979 title "T1-Weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease" @default.
- W1971287979 cites W1967922486 @default.
- W1971287979 cites W1968675038 @default.
- W1971287979 cites W1969044084 @default.
- W1971287979 cites W1974146533 @default.
- W1971287979 cites W1981014938 @default.
- W1971287979 cites W2005890826 @default.
- W1971287979 cites W2008560062 @default.
- W1971287979 cites W2017737272 @default.
- W1971287979 cites W2031583388 @default.
- W1971287979 cites W2032034564 @default.
- W1971287979 cites W2032870207 @default.
- W1971287979 cites W204017299 @default.
- W1971287979 cites W2050768160 @default.
- W1971287979 cites W2059118547 @default.
- W1971287979 cites W2061571431 @default.
- W1971287979 cites W2064996887 @default.
- W1971287979 cites W2073760242 @default.
- W1971287979 cites W2082012710 @default.
- W1971287979 cites W2086361121 @default.
- W1971287979 cites W2092462980 @default.
- W1971287979 cites W2093977564 @default.
- W1971287979 cites W2096617917 @default.
- W1971287979 cites W2105071925 @default.
- W1971287979 cites W2117690918 @default.
- W1971287979 cites W2122683421 @default.
- W1971287979 cites W2123773443 @default.
- W1971287979 cites W2134143820 @default.
- W1971287979 cites W2149584897 @default.
- W1971287979 cites W2150676893 @default.
- W1971287979 cites W2298871813 @default.
- W1971287979 doi "https://doi.org/10.1002/mds.23722" @default.
- W1971287979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21491489" @default.
- W1971287979 hasPublicationYear "2011" @default.
- W1971287979 type Work @default.
- W1971287979 sameAs 1971287979 @default.
- W1971287979 citedByCount "154" @default.
- W1971287979 countsByYear W19712879792012 @default.
- W1971287979 countsByYear W19712879792013 @default.
- W1971287979 countsByYear W19712879792014 @default.
- W1971287979 countsByYear W19712879792015 @default.
- W1971287979 countsByYear W19712879792016 @default.
- W1971287979 countsByYear W19712879792017 @default.
- W1971287979 countsByYear W19712879792018 @default.
- W1971287979 countsByYear W19712879792019 @default.
- W1971287979 countsByYear W19712879792020 @default.
- W1971287979 countsByYear W19712879792021 @default.
- W1971287979 countsByYear W19712879792022 @default.
- W1971287979 countsByYear W19712879792023 @default.
- W1971287979 crossrefType "journal-article" @default.
- W1971287979 hasAuthorship W1971287979A5007912600 @default.
- W1971287979 hasAuthorship W1971287979A5025188319 @default.
- W1971287979 hasAuthorship W1971287979A5072684321 @default.
- W1971287979 hasAuthorship W1971287979A5076384706 @default.
- W1971287979 hasAuthorship W1971287979A5077230679 @default.
- W1971287979 hasAuthorship W1971287979A5078023911 @default.
- W1971287979 hasConcept C126838900 @default.
- W1971287979 hasConcept C142724271 @default.
- W1971287979 hasConcept C143409427 @default.
- W1971287979 hasConcept C15744967 @default.
- W1971287979 hasConcept C169760540 @default.
- W1971287979 hasConcept C2776773494 @default.
- W1971287979 hasConcept C2779134260 @default.
- W1971287979 hasConcept C2779734285 @default.
- W1971287979 hasConcept C2780938664 @default.
- W1971287979 hasConcept C43310041 @default.
- W1971287979 hasConcept C71924100 @default.
- W1971287979 hasConceptScore W1971287979C126838900 @default.
- W1971287979 hasConceptScore W1971287979C142724271 @default.
- W1971287979 hasConceptScore W1971287979C143409427 @default.
- W1971287979 hasConceptScore W1971287979C15744967 @default.
- W1971287979 hasConceptScore W1971287979C169760540 @default.
- W1971287979 hasConceptScore W1971287979C2776773494 @default.
- W1971287979 hasConceptScore W1971287979C2779134260 @default.
- W1971287979 hasConceptScore W1971287979C2779734285 @default.
- W1971287979 hasConceptScore W1971287979C2780938664 @default.
- W1971287979 hasConceptScore W1971287979C43310041 @default.
- W1971287979 hasConceptScore W1971287979C71924100 @default.
- W1971287979 hasIssue "9" @default.
- W1971287979 hasLocation W19712879791 @default.
- W1971287979 hasLocation W19712879792 @default.
- W1971287979 hasOpenAccess W1971287979 @default.
- W1971287979 hasPrimaryLocation W19712879791 @default.
- W1971287979 hasRelatedWork W1558984540 @default.
- W1971287979 hasRelatedWork W1975640329 @default.
- W1971287979 hasRelatedWork W2073396373 @default.
- W1971287979 hasRelatedWork W2086361121 @default.
- W1971287979 hasRelatedWork W2123812707 @default.