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- W1971290896 abstract "Background. Small bowel allografts can either be placed heterotopically or orthotopically. In heterotopic small bowel transplantation (H-SBT), the host small intestine containing a substantial amount of gut-associated lymphoid tissue is removed, whereas in conventional orthotopic small bowel transplantation (O-SBT) it is retained. This study compared the allograft survival of H-SBT and O-SBT and evaluated the effect of retaining the host intestine in O-SBT in an altered O-SBT (AO-SBT) model. Methods. SBT was performed in a high-responder rat stain combination (blood group D Agouti → Lewis). Immunosuppressive treatment consisting of a short course of FK506 (2 mg/kg/day IM for 3 days before transplantation and 0.3 mg/kg/day for 14 days after transplantation) was used. Results. Survival (mean ± SD) of H-, O-, and AO-SBT untreated animals was 6.25±0.58 days, 6.5±0.58 days, and 6.7±0.25 days, respectively. With FK506 immunosuppression, survival of H-SBT animals was 49.3±13.17 days, whereas 75% (12/16) and 80% (4/5), respectively, of O-SBT and AO-SBT animals achieved indefinite survival (>120 days) with functioning grafts. Conclusion. Our data suggest that heterotopic placement of intestinal allografts results in a more severe graft rejection than orthotopic placement. The indefinite survival of O-SBT is not due to of the removal of host intestine carrying a heavy load of gut-associated lymphoid tissue." @default.
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- W1971290896 date "2003-06-15" @default.
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- W1971290896 title "Comparative study of allograft survival of heterotopic and orthotopic small bowel transplantation in rat1" @default.
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- W1971290896 doi "https://doi.org/10.1097/01.tp.0000065294.04793.11" @default.
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