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- W1971291157 abstract "RATIONALE: Self-injectable epinephrine (E) is underutilized in the first-aid treatment of anaphylaxis in the community. We hypothesized that sublingual E from novel fast-disintegrating tablets would result in E plasma concentrations (EPC) similar to those obtained after E 0.3 mg IM injection. METHODS: In a cross-over study, sublingual tablets containing E 0, 10, 20, and 40 mg, and EpiPen® (E 0.3 mg) were compared in a validated rabbit model. Sublingual tablets were retained under the tongue for 5 min. EpiPen® was injected in the thigh. Blood was collected before dosing and 5, 10, 15, 20, 30, 40, 60, 90, 120, 150, and 180 min afterwards. EPC were measured using HPLC-EC. Data were analysed using repeated measures ANOVA and Tukey-Kramer tests, NCSS program (p< 0.05). RESULTS: The area under the plasma concentration versus time curves (AUC) of tablets containing E 0 mg (AUC=547 ng/ml/min), E 10 mg (AUC=335 ng/ml/min), and E 20 mg (AUC=801 ng/ml/min) did not differ significantly from each other, but were significantly lower (p<0.05) than the AUC after E 40 mg (AUC=1,861 ng/ml/min) and after EpiPen® (AUC=2,431 ng/ml/min). The AUC, maximum plasma concentration (Cmax), and time of maximum plasma concentration (Tmax) after E 40 mg (AUC=1,861 ng/ml/min, Cmax= 27.5 ng/ml, and Tmax=15 min) and EpiPen® (AUC=2,431 ng/ml/min, Cmax=29.0 ng/ml, and Tmax=10 min) did not differ significantly from each other. CONCLUSIONS: In this model, sublingual administration of E 40 mg resulted in EPC similar to those obtained after E 0.3 mg IM injection in the thigh." @default.
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- W1971291157 date "2006-02-01" @default.
- W1971291157 modified "2023-09-25" @default.
- W1971291157 title "Sublingual Epinephrine Tablets Versus EpiPen: Dose Equivalence for Potential First-Aid Treatment of Anaphylaxis" @default.
- W1971291157 doi "https://doi.org/10.1016/j.jaci.2005.12.343" @default.
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