FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971291256> ?p ?o ?g. }

• W1971291256 endingPage "356" @default.
• W1971291256 startingPage "356" @default.
• W1971291256 abstract "To identify the genes related to lymph node metastasis in human hepatocellular carcinoma (HCC), 32 HCC patients with or without lymph node metastasis were investigated by high-throughput microarray comprising 886 genes.The samples of cancerous and non-cancerous paired tissue were taken from 32 patients with HCC who underwent hepatectomy with lymph node dissection. Total RNA was extracted from the cells obtained by means of laser microdissection (LCM) and was amplified by the T7-based amplification system. Then, the amplified samples were applied in the cDNA microarray comprising of 886 genes.The results demonstrated that 25 up-regulated genes such as cell membrane receptor, intracellular signaling and cell adhesion related genes, and 48 down-regulated genes such as intracellular signaling and cell cycle regulator-related genes, were correlated with lymph node metastasis in HCC. Amongst them were included some interesting genes, such as MET, EPHA2, CCND1, MMP2, MMP13, CASP3, CDH1, and PTPN2. Expression of 16 genes (MET, CCND1, CCND2, VEGF, KRT18, RFC4, BIRC5, CDC6, MMP2, BCL2A1, CDH1, VIM, PDGFRA, PTPN2, SLC25A5 and DSP) were further confirmed by real-time quantitative reverse transcriptional polymerase chain reaction (RT-PCR).Tumor metastasis is an important biological characteristic, which involves multiple genetic changes and cumulation. This genome-wide information contributes to an improved understanding of molecular alterations during lymph node metastasis in HCC. It may help clinicians to predict metastasis of lymph nodes and assist researchers in identifying novel therapeutic targets for metastatic HCC patients." @default.
• W1971291256 created "2016-06-24" @default.
• W1971291256 creator A5014590633 @default.
• W1971291256 creator A5016818960 @default.
• W1971291256 creator A5032365671 @default.
• W1971291256 creator A5033557335 @default.
• W1971291256 creator A5047986193 @default.
• W1971291256 creator A5054317718 @default.
• W1971291256 creator A5072515446 @default.
• W1971291256 date "2009-01-01" @default.
• W1971291256 modified "2023-10-18" @default.
• W1971291256 title "Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma" @default.
• W1971291256 cites W1571141347 @default.
• W1971291256 cites W1620997626 @default.
• W1971291256 cites W1964711158 @default.
• W1971291256 cites W1966392018 @default.
• W1971291256 cites W1967616608 @default.
• W1971291256 cites W1970218988 @default.
• W1971291256 cites W1971529620 @default.
• W1971291256 cites W1981791870 @default.
• W1971291256 cites W1986075282 @default.
• W1971291256 cites W1987233758 @default.
• W1971291256 cites W1989151475 @default.
• W1971291256 cites W1989908520 @default.
• W1971291256 cites W1994045147 @default.
• W1971291256 cites W1997858491 @default.
• W1971291256 cites W1998550865 @default.
• W1971291256 cites W2002874107 @default.
• W1971291256 cites W2018803551 @default.
• W1971291256 cites W2032465737 @default.
• W1971291256 cites W2032600439 @default.
• W1971291256 cites W2046513138 @default.
• W1971291256 cites W2053448633 @default.
• W1971291256 cites W2057113047 @default.
• W1971291256 cites W2059216678 @default.
• W1971291256 cites W2068672560 @default.
• W1971291256 cites W2071731434 @default.
• W1971291256 cites W2094385406 @default.
• W1971291256 cites W2094663537 @default.
• W1971291256 cites W2096808350 @default.
• W1971291256 cites W2099102308 @default.
• W1971291256 cites W2099220382 @default.
• W1971291256 cites W2105562862 @default.
• W1971291256 cites W2128333867 @default.
• W1971291256 cites W2128446760 @default.
• W1971291256 cites W2131374491 @default.
• W1971291256 cites W2131962318 @default.
• W1971291256 cites W2134678284 @default.
• W1971291256 cites W2135056923 @default.
• W1971291256 cites W2156031796 @default.
• W1971291256 cites W2156794452 @default.
• W1971291256 cites W2157114107 @default.
• W1971291256 cites W2158401328 @default.
• W1971291256 cites W2158697148 @default.
• W1971291256 cites W2161214210 @default.
• W1971291256 cites W2169229217 @default.
• W1971291256 cites W2321119966 @default.
• W1971291256 cites W2325613032 @default.
• W1971291256 cites W2089718274 @default.
• W1971291256 doi "https://doi.org/10.3748/wjg.15.356" @default.
• W1971291256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2653334" @default.
• W1971291256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19140237" @default.
• W1971291256 hasPublicationYear "2009" @default.
• W1971291256 type Work @default.
• W1971291256 sameAs 1971291256 @default.
• W1971291256 citedByCount "49" @default.
• W1971291256 countsByYear W19712912562012 @default.
• W1971291256 countsByYear W19712912562013 @default.
• W1971291256 countsByYear W19712912562014 @default.
• W1971291256 countsByYear W19712912562015 @default.
• W1971291256 countsByYear W19712912562016 @default.
• W1971291256 countsByYear W19712912562017 @default.
• W1971291256 countsByYear W19712912562018 @default.
• W1971291256 countsByYear W19712912562019 @default.
• W1971291256 countsByYear W19712912562020 @default.
• W1971291256 countsByYear W19712912562021 @default.
• W1971291256 countsByYear W19712912562022 @default.
• W1971291256 countsByYear W19712912562023 @default.
• W1971291256 crossrefType "journal-article" @default.
• W1971291256 hasAuthorship W1971291256A5014590633 @default.
• W1971291256 hasAuthorship W1971291256A5016818960 @default.
• W1971291256 hasAuthorship W1971291256A5032365671 @default.
• W1971291256 hasAuthorship W1971291256A5033557335 @default.
• W1971291256 hasAuthorship W1971291256A5047986193 @default.
• W1971291256 hasAuthorship W1971291256A5054317718 @default.
• W1971291256 hasAuthorship W1971291256A5072515446 @default.
• W1971291256 hasBestOaLocation W19712912561 @default.
• W1971291256 hasConcept C104317684 @default.
• W1971291256 hasConcept C11242284 @default.
• W1971291256 hasConcept C121608353 @default.
• W1971291256 hasConcept C125965507 @default.
• W1971291256 hasConcept C142724271 @default.
• W1971291256 hasConcept C150194340 @default.
• W1971291256 hasConcept C186836561 @default.
• W1971291256 hasConcept C2779013556 @default.
• W1971291256 hasConcept C2780699576 @default.
• W1971291256 hasConcept C502942594 @default.
• W1971291256 hasConcept C54355233 @default.

• next