FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971292277> ?p ?o ?g. }

• W1971292277 endingPage "21" @default.
• W1971292277 startingPage "17" @default.
• W1971292277 abstract "Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in cell culture by 4 log units with an IC90 of 110 μM. Mice lacking the type I interferon receptor (IFNAR−/−) were used as in vivo model for Zaire EBOV-induced disease. Initiation of T-705 administration at day 6 post infection induced rapid virus clearance, reduced biochemical parameters of disease severity, and prevented a lethal outcome in 100% of the animals. The findings suggest that T-705 is a candidate for treatment of Ebola hemorrhagic fever." @default.
• W1971292277 created "2016-06-24" @default.
• W1971292277 creator A5008655090 @default.
• W1971292277 creator A5015182596 @default.
• W1971292277 creator A5044516121 @default.
• W1971292277 creator A5051191695 @default.
• W1971292277 creator A5075527420 @default.
• W1971292277 creator A5080840230 @default.
• W1971292277 date "2014-05-01" @default.
• W1971292277 modified "2023-10-16" @default.
• W1971292277 title "Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model" @default.
• W1971292277 cites W1543288877 @default.
• W1971292277 cites W1988126326 @default.
• W1971292277 cites W2013539008 @default.
• W1971292277 cites W2018928802 @default.
• W1971292277 cites W2030160453 @default.
• W1971292277 cites W2037162459 @default.
• W1971292277 cites W2039941020 @default.
• W1971292277 cites W2050169388 @default.
• W1971292277 cites W2050813818 @default.
• W1971292277 cites W2056956872 @default.
• W1971292277 cites W2060514161 @default.
• W1971292277 cites W2086367918 @default.
• W1971292277 cites W2098900577 @default.
• W1971292277 cites W2102286438 @default.
• W1971292277 cites W2108367829 @default.
• W1971292277 cites W2109986071 @default.
• W1971292277 cites W2117671399 @default.
• W1971292277 cites W2125684318 @default.
• W1971292277 cites W2127911548 @default.
• W1971292277 cites W2128406623 @default.
• W1971292277 cites W2131909499 @default.
• W1971292277 cites W2132345575 @default.
• W1971292277 cites W2138274210 @default.
• W1971292277 cites W2140965090 @default.
• W1971292277 cites W2150837053 @default.
• W1971292277 cites W2154270538 @default.
• W1971292277 cites W2166596830 @default.
• W1971292277 doi "https://doi.org/10.1016/j.antiviral.2014.02.014" @default.
• W1971292277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24583123" @default.
• W1971292277 hasPublicationYear "2014" @default.
• W1971292277 type Work @default.
• W1971292277 sameAs 1971292277 @default.
• W1971292277 citedByCount "425" @default.
• W1971292277 countsByYear W19712922772014 @default.
• W1971292277 countsByYear W19712922772015 @default.
• W1971292277 countsByYear W19712922772016 @default.
• W1971292277 countsByYear W19712922772017 @default.
• W1971292277 countsByYear W19712922772018 @default.
• W1971292277 countsByYear W19712922772019 @default.
• W1971292277 countsByYear W19712922772020 @default.
• W1971292277 countsByYear W19712922772021 @default.
• W1971292277 countsByYear W19712922772022 @default.
• W1971292277 countsByYear W19712922772023 @default.
• W1971292277 crossrefType "journal-article" @default.
• W1971292277 hasAuthorship W1971292277A5008655090 @default.
• W1971292277 hasAuthorship W1971292277A5015182596 @default.
• W1971292277 hasAuthorship W1971292277A5044516121 @default.
• W1971292277 hasAuthorship W1971292277A5051191695 @default.
• W1971292277 hasAuthorship W1971292277A5075527420 @default.
• W1971292277 hasAuthorship W1971292277A5080840230 @default.
• W1971292277 hasBestOaLocation W19712922771 @default.
• W1971292277 hasConcept C107130276 @default.
• W1971292277 hasConcept C116675565 @default.
• W1971292277 hasConcept C126322002 @default.
• W1971292277 hasConcept C150903083 @default.
• W1971292277 hasConcept C159047783 @default.
• W1971292277 hasConcept C187316915 @default.
• W1971292277 hasConcept C203014093 @default.
• W1971292277 hasConcept C207001950 @default.
• W1971292277 hasConcept C2522874641 @default.
• W1971292277 hasConcept C2777469322 @default.
• W1971292277 hasConcept C2779134260 @default.
• W1971292277 hasConcept C2779772310 @default.
• W1971292277 hasConcept C2909623084 @default.
• W1971292277 hasConcept C2910344980 @default.
• W1971292277 hasConcept C3008058167 @default.
• W1971292277 hasConcept C524204448 @default.
• W1971292277 hasConcept C71924100 @default.
• W1971292277 hasConcept C86803240 @default.
• W1971292277 hasConceptScore W1971292277C107130276 @default.
• W1971292277 hasConceptScore W1971292277C116675565 @default.
• W1971292277 hasConceptScore W1971292277C126322002 @default.
• W1971292277 hasConceptScore W1971292277C150903083 @default.
• W1971292277 hasConceptScore W1971292277C159047783 @default.
• W1971292277 hasConceptScore W1971292277C187316915 @default.
• W1971292277 hasConceptScore W1971292277C203014093 @default.
• W1971292277 hasConceptScore W1971292277C207001950 @default.
• W1971292277 hasConceptScore W1971292277C2522874641 @default.
• W1971292277 hasConceptScore W1971292277C2777469322 @default.
• W1971292277 hasConceptScore W1971292277C2779134260 @default.
• W1971292277 hasConceptScore W1971292277C2779772310 @default.
• W1971292277 hasConceptScore W1971292277C2909623084 @default.
• W1971292277 hasConceptScore W1971292277C2910344980 @default.
• W1971292277 hasConceptScore W1971292277C3008058167 @default.
• W1971292277 hasConceptScore W1971292277C524204448 @default.
• W1971292277 hasConceptScore W1971292277C71924100 @default.
• W1971292277 hasConceptScore W1971292277C86803240 @default.

• next