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- W1971292710 endingPage "435" @default.
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- W1971292710 abstract "Chronic lymphocytic leukemia (CLL) is the most common leukaemia in the Western world. Recent advancement in the aetiology, pathophysiology and the development of new therapeutics tools have significantly modified the current management of CLL.The cellular origin of CLL is still unknown. The current main hypothesis will be first briefly described. This review will then focus on the newly defined prognostic factors and the development and use of new drugs for the treatment of CLL. To describe the modern and practical management of CLL, we will compare classical and new prognostic markers. Then, we will discuss the various therapeutic options including chemotherapy and immunotherapy (monoclonal antibodies, allogenic transplantation), and define their current respective indications.These new diagnostic and prognostic markers will allow the characterization of new prognostic subgroups of patients. This will lead to a targeted and individualized therapeutic approach. We will present the first results of clinical trials and the on-going studies conducted in this disease." @default.
- W1971292710 created "2016-06-24" @default.
- W1971292710 creator A5000969643 @default.
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- W1971292710 creator A5059074504 @default.
- W1971292710 creator A5085831038 @default.
- W1971292710 creator A5091498423 @default.
- W1971292710 date "2008-05-01" @default.
- W1971292710 modified "2023-10-02" @default.
- W1971292710 title "Prise en charge actuelle de la leucémie lymphoïde chronique" @default.
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- W1971292710 doi "https://doi.org/10.1016/j.revmed.2007.10.414" @default.