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• W1971292717 abstract "<h3>Background and objectives</h3> Increased water intake may benefit kidney function. Prior to initiating a larger randomised controlled trial (RCT), we examined the safety and feasibility of asking adults with chronic kidney disease (CKD) to increase their water intake. <h3>Design, setting, participants and measurements</h3> Beginning in October 2012, we randomly assigned 29 adults with stage 3 CKD (estimated glomerular filtration rate (eGFR) 30–60 mL/min/1.73 m² and albuminuria) to one of the two groups of water intake: hydration (n=18) or standard (n=11). We asked the hydration group to increase their water intake by 1.0–1.5 L/day (in addition to usual intake, depending on sex and weight) for 6 weeks, while the control group carried on with their usual intake. Participants collected a 24 h urine sample at baseline and at 2 and 6 weeks after randomisation. Our primary outcome was the between-group difference in change in 24 h urine volume from baseline to 6 weeks. <h3>Results</h3> (63%)of participants were men, 81% were Caucasians and the average age was 61 years (SD 14 years). The average baseline eGFR was 40 mL/min/1.73 m² (SD 11 mL/min/1.73 m²); the median albumin to creatinine ratio was 19 mg/mmol (IQR 6–74 mg/mmol). Between baseline and 6-week follow-up, the hydration group9s average 24 h urine volume increased by 0.7 L/day (from 2.3 to 3.0 L/day) and the control group9s 24 h urine decreased by 0.3 L/day (from 2.0 to 1.7 L/day; between-group difference in change: 0.9 L/day (95% CI 0.4 to 1.5; p=0.002)). We found no significant changes in urine, serum osmolality or electrolyte concentrations, or eGFR. No serious adverse events or changes in quality of life were reported. <h3>Conclusions</h3> A pilot RCT indicates adults with stage 3 CKD can successfully and safely increase water intake by up to 0.7 L/day in addition to usual fluid intake. <h3>Trial registration Registered with Clinical Trials—government identifier</h3> NCT01753466." @default.
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• W1971292717 date "1994-01-29" @default.
• W1971292717 modified "2023-09-25" @default.
• W1971292717 title "Randomised controlled trial evaluating cardiovascular screening and intervention in general practice: principal results of British family heart study" @default.
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• W1971292717 doi "https://doi.org/10.1136/bmj.308.6924.313" @default.
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