Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971294322> ?p ?o ?g. }
- W1971294322 endingPage "8880" @default.
- W1971294322 startingPage "8865" @default.
- W1971294322 abstract "WW domains are small modules present in regulatory and signaling proteins that mediate specific protein-protein interactions. The WW domain-containing oxidoreductase (WWOX) encodes a 46-kDa tumor suppressor that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. Based on its ligand recognition motifs, the WW domain family is classified into four groups. The largest one, to which WWOX belongs, recognizes ligands with a PPXY motif. To pursue the functional properties of the WW domains of WWOX, we employed mass spectrometry and phage display experiments to identify putative WWOX-interacting partners. Our analysis revealed that the first WW (WW1) domain of WWOX is the main functional interacting domain. Furthermore, our study uncovered well known and new PPXY-WW1-interacting partners and shed light on novel LPXY-WW1-interacting partners of WWOX. Many of these proteins are components of multiprotein complexes involved in molecular processes, including transcription, RNA processing, tight junction, and metabolism. By utilizing GST pull-down and immunoprecipitation assays, we validated that WWOX is a substrate of the E3 ubiquitin ligase ITCH, which contains two LPXY motifs. We found that ITCH mediates Lys-63-linked polyubiquitination of WWOX, leading to its nuclear localization and increased cell death. Our data suggest that the WW1 domain of WWOX provides a versatile platform that links WWOX with individual proteins associated with physiologically important networks." @default.
- W1971294322 created "2016-06-24" @default.
- W1971294322 creator A5008365973 @default.
- W1971294322 creator A5017297567 @default.
- W1971294322 creator A5021249524 @default.
- W1971294322 creator A5028316931 @default.
- W1971294322 creator A5035936668 @default.
- W1971294322 creator A5043262709 @default.
- W1971294322 creator A5044259899 @default.
- W1971294322 creator A5058298248 @default.
- W1971294322 creator A5076195752 @default.
- W1971294322 creator A5080721505 @default.
- W1971294322 creator A5091017060 @default.
- W1971294322 date "2014-03-01" @default.
- W1971294322 modified "2023-10-17" @default.
- W1971294322 title "Characterizing WW Domain Interactions of Tumor Suppressor WWOX Reveals Its Association with Multiprotein Networks" @default.
- W1971294322 cites W1550989298 @default.
- W1971294322 cites W1963902950 @default.
- W1971294322 cites W1973858755 @default.
- W1971294322 cites W1976436001 @default.
- W1971294322 cites W1979395827 @default.
- W1971294322 cites W1979629343 @default.
- W1971294322 cites W1982260089 @default.
- W1971294322 cites W1987972154 @default.
- W1971294322 cites W1992970966 @default.
- W1971294322 cites W1999948064 @default.
- W1971294322 cites W2003519286 @default.
- W1971294322 cites W2007731525 @default.
- W1971294322 cites W2009126761 @default.
- W1971294322 cites W2010589579 @default.
- W1971294322 cites W2013248580 @default.
- W1971294322 cites W2014522293 @default.
- W1971294322 cites W2015338902 @default.
- W1971294322 cites W2033152875 @default.
- W1971294322 cites W2043685957 @default.
- W1971294322 cites W2044042744 @default.
- W1971294322 cites W2047107715 @default.
- W1971294322 cites W2048472525 @default.
- W1971294322 cites W2049480511 @default.
- W1971294322 cites W2050219428 @default.
- W1971294322 cites W2066812797 @default.
- W1971294322 cites W2067343115 @default.
- W1971294322 cites W2070268999 @default.
- W1971294322 cites W2071917062 @default.
- W1971294322 cites W2074570440 @default.
- W1971294322 cites W2077469182 @default.
- W1971294322 cites W2077494922 @default.
- W1971294322 cites W2077725608 @default.
- W1971294322 cites W2079828953 @default.
- W1971294322 cites W2079943669 @default.
- W1971294322 cites W2081466880 @default.
- W1971294322 cites W2081511916 @default.
- W1971294322 cites W2084739125 @default.
- W1971294322 cites W2086172275 @default.
- W1971294322 cites W2086959309 @default.
- W1971294322 cites W2093201959 @default.
- W1971294322 cites W2093230990 @default.
- W1971294322 cites W2095366249 @default.
- W1971294322 cites W2096845735 @default.
- W1971294322 cites W2099982459 @default.
- W1971294322 cites W2102053088 @default.
- W1971294322 cites W2103079233 @default.
- W1971294322 cites W2108260772 @default.
- W1971294322 cites W2117754842 @default.
- W1971294322 cites W2119054256 @default.
- W1971294322 cites W2122976298 @default.
- W1971294322 cites W2127295427 @default.
- W1971294322 cites W2131740501 @default.
- W1971294322 cites W2132633443 @default.
- W1971294322 cites W2132646376 @default.
- W1971294322 cites W2133465414 @default.
- W1971294322 cites W2136683006 @default.
- W1971294322 cites W2139447006 @default.
- W1971294322 cites W2143727653 @default.
- W1971294322 cites W2144663664 @default.
- W1971294322 cites W2147087392 @default.
- W1971294322 cites W2149966409 @default.
- W1971294322 cites W2150185773 @default.
- W1971294322 cites W2153056550 @default.
- W1971294322 cites W2158217645 @default.
- W1971294322 cites W2166732297 @default.
- W1971294322 cites W2169462450 @default.
- W1971294322 cites W2314005406 @default.
- W1971294322 doi "https://doi.org/10.1074/jbc.m113.506790" @default.
- W1971294322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3979411" @default.
- W1971294322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24550385" @default.
- W1971294322 hasPublicationYear "2014" @default.
- W1971294322 type Work @default.
- W1971294322 sameAs 1971294322 @default.
- W1971294322 citedByCount "82" @default.
- W1971294322 countsByYear W19712943222014 @default.
- W1971294322 countsByYear W19712943222015 @default.
- W1971294322 countsByYear W19712943222016 @default.
- W1971294322 countsByYear W19712943222017 @default.
- W1971294322 countsByYear W19712943222018 @default.
- W1971294322 countsByYear W19712943222019 @default.
- W1971294322 countsByYear W19712943222020 @default.
- W1971294322 countsByYear W19712943222021 @default.