FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971296513> ?p ?o ?g. }

• W1971296513 endingPage "338" @default.
• W1971296513 startingPage "327" @default.
• W1971296513 abstract "Male Wistar rats were exposed by inhalation to N,N-dimethylformamide (DMF) at 0 (control), 200 or 400 ppm (v/v) for 6 hr/day, 5 days/week and 4 weeks, and each inhalation group received DMF-formulated drinking water at 0, 800, 1,600 or 3,200 ppm (w/w) for 24 hr/day, 7 days/week and 4 weeks. Both the combined inhalation and oral exposures and the single-route exposure through inhalation or ingestion induced centrilobular hypertrophy and single-cell necrosis of hepatocytes, increased plasma levels of alanine aminotransferase (ALT), increased percentage of proliferating cell nuclear antigen (PCNA)-positive hepatocytes without glutathione-S-transferase placental form (GST-P)-positive liver foci, and increased relative liver weight. Those hepatic parameters of the DMF-induced effects were classified into hypertrophic, necrotic and proliferative responses according to the pathological characteristics of affected liver. While magnitudes of the hypertrophic and necrotic responses were linearly increased with an increase in amounts of DMF uptake in the single-route exposure groups, those dose-response relationships tended to level off in the combined-exposure groups. Saturation of the hypertrophic and necrotic responses at high dose levels might be attributed to suppression of the metabolic conversion of DMF to its toxic metabolites. Percentage of PCNA-stained hepatocytes classified as the proliferative response was increased more steeply in the combined-exposure groups than in the single-route exposure groups. It was suggested that the proliferative response of hepatocytes to the combined exposures would be greater than that which would be expected under an assumption of additivity for the component proliferative responses to the single-route exposures through inhalation and ingestion." @default.
• W1971296513 created "2016-06-24" @default.
• W1971296513 creator A5000282495 @default.
• W1971296513 creator A5014503290 @default.
• W1971296513 creator A5034451712 @default.
• W1971296513 creator A5044505935 @default.
• W1971296513 creator A5066571069 @default.
• W1971296513 creator A5071836414 @default.
• W1971296513 date "2008-01-01" @default.
• W1971296513 modified "2023-10-04" @default.
• W1971296513 title "Enhanced proliferative response of hepatocytes to combined inhalation and oral exposures to N,N-dimethylformamide in male rats" @default.
• W1971296513 cites W1557027369 @default.
• W1971296513 cites W1970036425 @default.
• W1971296513 cites W1976152197 @default.
• W1971296513 cites W1981895452 @default.
• W1971296513 cites W1986625855 @default.
• W1971296513 cites W1988945889 @default.
• W1971296513 cites W1989634531 @default.
• W1971296513 cites W1994510051 @default.
• W1971296513 cites W1997692020 @default.
• W1971296513 cites W2042794188 @default.
• W1971296513 cites W2044089754 @default.
• W1971296513 cites W2054459232 @default.
• W1971296513 cites W2063789937 @default.
• W1971296513 cites W2063970068 @default.
• W1971296513 cites W2064044399 @default.
• W1971296513 cites W2069231524 @default.
• W1971296513 cites W2079358955 @default.
• W1971296513 cites W2079446105 @default.
• W1971296513 cites W2079760714 @default.
• W1971296513 cites W2080443958 @default.
• W1971296513 cites W2092024091 @default.
• W1971296513 cites W2096491611 @default.
• W1971296513 cites W2111106093 @default.
• W1971296513 cites W2113892225 @default.
• W1971296513 cites W2128617566 @default.
• W1971296513 cites W2144389227 @default.
• W1971296513 cites W2152604676 @default.
• W1971296513 cites W2157356622 @default.
• W1971296513 cites W2158999905 @default.
• W1971296513 cites W2312977193 @default.
• W1971296513 cites W3023577839 @default.
• W1971296513 doi "https://doi.org/10.2131/jts.33.327" @default.
• W1971296513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18670164" @default.
• W1971296513 hasPublicationYear "2008" @default.
• W1971296513 type Work @default.
• W1971296513 sameAs 1971296513 @default.
• W1971296513 citedByCount "11" @default.
• W1971296513 countsByYear W19712965132012 @default.
• W1971296513 countsByYear W19712965132013 @default.
• W1971296513 countsByYear W19712965132015 @default.
• W1971296513 countsByYear W19712965132016 @default.
• W1971296513 countsByYear W19712965132017 @default.
• W1971296513 countsByYear W19712965132021 @default.
• W1971296513 crossrefType "journal-article" @default.
• W1971296513 hasAuthorship W1971296513A5000282495 @default.
• W1971296513 hasAuthorship W1971296513A5014503290 @default.
• W1971296513 hasAuthorship W1971296513A5034451712 @default.
• W1971296513 hasAuthorship W1971296513A5044505935 @default.
• W1971296513 hasAuthorship W1971296513A5066571069 @default.
• W1971296513 hasAuthorship W1971296513A5071836414 @default.
• W1971296513 hasBestOaLocation W19712965131 @default.
• W1971296513 hasConcept C126322002 @default.
• W1971296513 hasConcept C134018914 @default.
• W1971296513 hasConcept C16685009 @default.
• W1971296513 hasConcept C181199279 @default.
• W1971296513 hasConcept C185592680 @default.
• W1971296513 hasConcept C193230392 @default.
• W1971296513 hasConcept C202751555 @default.
• W1971296513 hasConcept C2776200302 @default.
• W1971296513 hasConcept C2776954882 @default.
• W1971296513 hasConcept C2779777708 @default.
• W1971296513 hasConcept C29730261 @default.
• W1971296513 hasConcept C34688535 @default.
• W1971296513 hasConcept C42219234 @default.
• W1971296513 hasConcept C503630168 @default.
• W1971296513 hasConcept C538909803 @default.
• W1971296513 hasConcept C55493867 @default.
• W1971296513 hasConcept C62112901 @default.
• W1971296513 hasConcept C71924100 @default.
• W1971296513 hasConceptScore W1971296513C126322002 @default.
• W1971296513 hasConceptScore W1971296513C134018914 @default.
• W1971296513 hasConceptScore W1971296513C16685009 @default.
• W1971296513 hasConceptScore W1971296513C181199279 @default.
• W1971296513 hasConceptScore W1971296513C185592680 @default.
• W1971296513 hasConceptScore W1971296513C193230392 @default.
• W1971296513 hasConceptScore W1971296513C202751555 @default.
• W1971296513 hasConceptScore W1971296513C2776200302 @default.
• W1971296513 hasConceptScore W1971296513C2776954882 @default.
• W1971296513 hasConceptScore W1971296513C2779777708 @default.
• W1971296513 hasConceptScore W1971296513C29730261 @default.
• W1971296513 hasConceptScore W1971296513C34688535 @default.
• W1971296513 hasConceptScore W1971296513C42219234 @default.
• W1971296513 hasConceptScore W1971296513C503630168 @default.
• W1971296513 hasConceptScore W1971296513C538909803 @default.
• W1971296513 hasConceptScore W1971296513C55493867 @default.
• W1971296513 hasConceptScore W1971296513C62112901 @default.
• W1971296513 hasConceptScore W1971296513C71924100 @default.

• next