Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971296640> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1971296640 endingPage "e877" @default.
- W1971296640 startingPage "e877" @default.
- W1971296640 abstract "Despite the major public health importance of visceral leishmaniasis (VL) in Latin America, well-designed studies to inform diagnosis, treatment and control interventions are scarce. Few observational studies address prognostic assessment in patients with VL. This study aimed to identify risk factors for death in children aged less than 15 years admitted for VL treatment in a referral center in northeast Brazil.In a retrospective cohort, we reviewed 546 records of patients younger than 15 years admitted with the diagnosis of VL at the Instituto de Medicina Integral Professor Fernando Figueira between May 1996 and June 2006. Age ranged from 4 months to 13.7 years, and 275 (50%) were male. There were 57 deaths, with a case-fatality rate of 10%. In multivariate logistic regression, the independent predictors of risk of dying from VL were (adjusted OR, 95% CI): mucosal bleeding (4.1, 1.3-13.4), jaundice (4.4, 1.7-11.2), dyspnea (2.8, 1.2-6.1), suspected or confirmed bacterial infections (2.7, 1.2-6.1), neutrophil count <500/mm³ (3.1, 1.4-6.9) and platelet count <50,000/mm³ (11.7, 5.4-25.1). A prognostic score was proposed and had satisfactory sensitivity (88.7%) and specificity (78.5%).Prognostic and severity markers can be useful to inform clinical decisions such as whether a child with VL can be safely treated in the local healthcare facility or would potentially benefit from transfer to referral centers where advanced life support facilities are available. High risk patients may benefit from interventions such as early use of extended-spectrum antibiotics or transfusion of blood products. These baseline risk-based supportive interventions should be assessed in clinical trials." @default.
- W1971296640 created "2016-06-24" @default.
- W1971296640 creator A5035131505 @default.
- W1971296640 creator A5056321628 @default.
- W1971296640 creator A5058640459 @default.
- W1971296640 creator A5065614437 @default.
- W1971296640 creator A5072265086 @default.
- W1971296640 date "2010-11-02" @default.
- W1971296640 modified "2023-10-07" @default.
- W1971296640 title "Risk Factors for Death in Children with Visceral Leishmaniasis" @default.
- W1971296640 cites W2051210731 @default.
- W1971296640 cites W2052276776 @default.
- W1971296640 cites W2052387345 @default.
- W1971296640 cites W2068215182 @default.
- W1971296640 cites W2092135249 @default.
- W1971296640 cites W2146292123 @default.
- W1971296640 cites W2172229788 @default.
- W1971296640 cites W4244989339 @default.
- W1971296640 cites W80142837 @default.
- W1971296640 doi "https://doi.org/10.1371/journal.pntd.0000877" @default.
- W1971296640 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2970542" @default.
- W1971296640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21072238" @default.
- W1971296640 hasPublicationYear "2010" @default.
- W1971296640 type Work @default.
- W1971296640 sameAs 1971296640 @default.
- W1971296640 citedByCount "52" @default.
- W1971296640 countsByYear W19712966402012 @default.
- W1971296640 countsByYear W19712966402013 @default.
- W1971296640 countsByYear W19712966402014 @default.
- W1971296640 countsByYear W19712966402015 @default.
- W1971296640 countsByYear W19712966402016 @default.
- W1971296640 countsByYear W19712966402017 @default.
- W1971296640 countsByYear W19712966402018 @default.
- W1971296640 countsByYear W19712966402020 @default.
- W1971296640 countsByYear W19712966402021 @default.
- W1971296640 countsByYear W19712966402022 @default.
- W1971296640 countsByYear W19712966402023 @default.
- W1971296640 crossrefType "journal-article" @default.
- W1971296640 hasAuthorship W1971296640A5035131505 @default.
- W1971296640 hasAuthorship W1971296640A5056321628 @default.
- W1971296640 hasAuthorship W1971296640A5058640459 @default.
- W1971296640 hasAuthorship W1971296640A5065614437 @default.
- W1971296640 hasAuthorship W1971296640A5072265086 @default.
- W1971296640 hasBestOaLocation W19712966401 @default.
- W1971296640 hasConcept C107130276 @default.
- W1971296640 hasConcept C118552586 @default.
- W1971296640 hasConcept C126322002 @default.
- W1971296640 hasConcept C167135981 @default.
- W1971296640 hasConcept C187212893 @default.
- W1971296640 hasConcept C187316915 @default.
- W1971296640 hasConcept C203014093 @default.
- W1971296640 hasConcept C23131810 @default.
- W1971296640 hasConcept C27415008 @default.
- W1971296640 hasConcept C2776135927 @default.
- W1971296640 hasConcept C2776555147 @default.
- W1971296640 hasConcept C2778689377 @default.
- W1971296640 hasConcept C512399662 @default.
- W1971296640 hasConcept C71924100 @default.
- W1971296640 hasConceptScore W1971296640C107130276 @default.
- W1971296640 hasConceptScore W1971296640C118552586 @default.
- W1971296640 hasConceptScore W1971296640C126322002 @default.
- W1971296640 hasConceptScore W1971296640C167135981 @default.
- W1971296640 hasConceptScore W1971296640C187212893 @default.
- W1971296640 hasConceptScore W1971296640C187316915 @default.
- W1971296640 hasConceptScore W1971296640C203014093 @default.
- W1971296640 hasConceptScore W1971296640C23131810 @default.
- W1971296640 hasConceptScore W1971296640C27415008 @default.
- W1971296640 hasConceptScore W1971296640C2776135927 @default.
- W1971296640 hasConceptScore W1971296640C2776555147 @default.
- W1971296640 hasConceptScore W1971296640C2778689377 @default.
- W1971296640 hasConceptScore W1971296640C512399662 @default.
- W1971296640 hasConceptScore W1971296640C71924100 @default.
- W1971296640 hasIssue "11" @default.
- W1971296640 hasLocation W19712966401 @default.
- W1971296640 hasLocation W19712966402 @default.
- W1971296640 hasLocation W19712966403 @default.
- W1971296640 hasLocation W19712966404 @default.
- W1971296640 hasOpenAccess W1971296640 @default.
- W1971296640 hasPrimaryLocation W19712966401 @default.
- W1971296640 hasRelatedWork W1573475535 @default.
- W1971296640 hasRelatedWork W1994496584 @default.
- W1971296640 hasRelatedWork W2005998302 @default.
- W1971296640 hasRelatedWork W2109147503 @default.
- W1971296640 hasRelatedWork W2184835667 @default.
- W1971296640 hasRelatedWork W2790827978 @default.
- W1971296640 hasRelatedWork W299029406 @default.
- W1971296640 hasRelatedWork W3158021702 @default.
- W1971296640 hasRelatedWork W3167139817 @default.
- W1971296640 hasRelatedWork W4381328000 @default.
- W1971296640 hasVolume "4" @default.
- W1971296640 isParatext "false" @default.
- W1971296640 isRetracted "false" @default.
- W1971296640 magId "1971296640" @default.
- W1971296640 workType "article" @default.