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- W1971301478 abstract "The molecular structure of 2α-hydroxyneoanisatin, a positional isomer of the potent neurotoxin anisatin, was determined by X-ray crystallographic analysis. This compound and four further seco-prezizaane type sesquiterpene lactones previously isolated from Illicium floridanum, which represent different structural types with respect to the mode of cyclisation, did not induce anisatin/picrotoxinin-like convulsions in mice. Based on these results and literature data for other seco-prezizaanes, structural requirements for convulsant activity are discussed. Comparison of the three dimensional molecular shape and electrostatic properties of active and inactive seco-prezizaane type lactones with compounds of the picrotoxane type resulted in the identification of a common pharmacophore structure for these different skeletal classes of convulsant natural products." @default.
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- W1971301478 title "The molecular structure of 2α-hydroxyneoanisatin and structure–activity relationships among convulsant sesquiterpenes of the seco-prezizaane and picrotoxane types" @default.
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- W1971301478 doi "https://doi.org/10.1016/s0968-0896(99)00240-0" @default.
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