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- W1971301837 endingPage "CMAMD.S6982" @default.
- W1971301837 startingPage "CMAMD.S6982" @default.
- W1971301837 abstract "Mechanical loading provides indispensible stimuli for growth and development of the articular cartilage and bone. Interestingly, depending on loading conditions loads applied to the joint can be beneficial as well as harmful to skeletal maintenance and remodeling. Moderate loads to the synovial joint, for instance, suppress the expression levels of matrix metallproteinases (MMPs), while loads above a threshold tend to increase their destructive activities. This report focuses on two recently developed loading modalities from animal studies, joint motion and joint loading. Their unique characteristics and potential usages for maintenance of the articular cartilage and stimulation of bone remodeling are reviewed. Also described are biophysical and molecular mechanisms which likely are responsible for the load-driven maintenance of cartilage and bone, and a possibility of developing load-mediated treatments of osteoporosis and osteoarthritis." @default.
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- W1971301837 date "2011-01-01" @default.
- W1971301837 modified "2023-10-11" @default.
- W1971301837 title "Mechanical Intervention for Maintenance of Cartilage and Bone" @default.
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- W1971301837 doi "https://doi.org/10.4137/cmamd.s6982" @default.
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