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- W1971307511 abstract "A raíz de la introducción del tratamiento antirretroviral de gran actividad (TARGA) la situación de los pacientes infectados por el virus de la inmunodeficiencia humana (VIH) ha cambiado radicalmente en los países desarrollados, habiendo mejorado tanto la supervivencia como la calidad de vida. Es ahora cuando comienzan a comunicarse las consecuencias a largo plazo de la infección por el VIH, como la osteoporosis, siendo numerosas las comunicaciones que hacen referencia a la mayor prevalencia de osteopenia y osteoporosis entre dichos pacientes. Consecuentemente se espera un aumento en el número de fracturas osteoporóticas. Entre los mecanismos responsables de la pérdida de masa ósea tenemos el efecto de la infección por el VIH y la terapia antirretroviral, siendo éste un tema de discusión controvertido que requerirá un mayor número de estudios. Revisamos aquí la osteoporosis en la población de pacientes con VIH centrándonos en los factores de riesgo y en los estudios que implican el tratamiento antirretroviral como agente etiológico y fundamentalmente el tenofovir. As a result of the introduction of high activity antiretroviral therapy (HAART), the situation of human immunodeficiency virus (HIV) infected patients has changed radically in developed countries. Both their survival and quality of life have improved. It is now when the long-term consequences, such as osteoporosis, of HIV infection are being communicated. There are many communications that refer to the greater prevalence of osteopenia and osteoporosis among these patients. Consequently, an increase in the number of osteoporotic fractures is to be expected. Among the mechanisms responsible for the loss of bone mass are the effect of HIV infection and antiretroviral therapy, this being a controversial subject of discussion that requires a greater number of studies. Herein, we review the osteoporosis in the HIV population, focusing on the risk factors and studies that involve antiretroviral treatment as an etiological agent and, fundamentally, tenofovir." @default.
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- W1971307511 date "2009-07-01" @default.
- W1971307511 modified "2023-09-25" @default.
- W1971307511 title "Tenofovir y enfermedad ósea en pacientes infectados por el VIH" @default.
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- W1971307511 doi "https://doi.org/10.1016/s1132-8460(09)73230-1" @default.
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