FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971319797> ?p ?o ?g. }

• W1971319797 endingPage "235" @default.
• W1971319797 startingPage "224" @default.
• W1971319797 abstract "In this article, we report the misdirected targeting of expressed aggrecan domains. Aggrecan, the chondroitin sulfate (CS) proteoglycan of cartilage, normally progresses through the exocytic pathway. Proteins expressed from constructs containing the putative aggrecan signal sequence (i.e., the first 23 N-terminal amino acids), specified globular (G) domains G1 and/or G3, and a segment of the CS domain were detected in the endoplasmic reticulum (ER) and Golgi complex. Although proteins expressed from constructs containing the putative signal and G3, but lacking G1, were detected to a limited extent in the secretory pathway, they primarily accumulated in nuclei. Discrete nuclear inclusions were seen when G3 was expressed. Immunoelectron microscopic characterization of the inclusions suggested the association of nuclear G3 with other proteins. When signal-free G3 constructs and those with G3 immediately following the N-terminal signal were expressed, abundant dispersed accumulations filled the nucleoplasm. The data suggest first, that signal-free and signal-containing G3 proteins enter the nucleus from the cytosol, and second, that the entry of signal-containing G3 proteins into the ER lumen is inefficient. Hsp25, Hsp70, and ubiquitin were colocalized with nuclear G3, indicating the involvement of chaperones and the degradative machinery in the formation and/or attempted disposal of the abnormal nuclear inclusions. Overall, the results focus attention on (1) intracellular protein trafficking at the ER membrane and the nuclear envelope and (2) chaperone interactions and mechanisms leading to abnormal protein deposition in the nucleus." @default.
• W1971319797 created "2016-06-24" @default.
• W1971319797 creator A5010562080 @default.
• W1971319797 creator A5020226093 @default.
• W1971319797 creator A5024602296 @default.
• W1971319797 creator A5030517507 @default.
• W1971319797 creator A5031319811 @default.
• W1971319797 creator A5061229411 @default.
• W1971319797 creator A5068778464 @default.
• W1971319797 creator A5080395353 @default.
• W1971319797 creator A5089517125 @default.
• W1971319797 date "2001-02-01" @default.
• W1971319797 modified "2023-09-27" @default.
• W1971319797 title "Aggrecan Domains Expected to Traffic through the Exocytic Pathway Are Misdirected to the Nucleus" @default.
• W1971319797 cites W1520564498 @default.
• W1971319797 cites W1556663915 @default.
• W1971319797 cites W1578056497 @default.
• W1971319797 cites W1607572308 @default.
• W1971319797 cites W1622884348 @default.
• W1971319797 cites W1751400903 @default.
• W1971319797 cites W1904784968 @default.
• W1971319797 cites W1945897416 @default.
• W1971319797 cites W1952548524 @default.
• W1971319797 cites W1968496776 @default.
• W1971319797 cites W1977922844 @default.
• W1971319797 cites W1981787059 @default.
• W1971319797 cites W1985474993 @default.
• W1971319797 cites W2007187871 @default.
• W1971319797 cites W2009975411 @default.
• W1971319797 cites W2015186431 @default.
• W1971319797 cites W2016580415 @default.
• W1971319797 cites W2016735583 @default.
• W1971319797 cites W2017985097 @default.
• W1971319797 cites W2020057670 @default.
• W1971319797 cites W2023271648 @default.
• W1971319797 cites W2024384954 @default.
• W1971319797 cites W2039863802 @default.
• W1971319797 cites W2042716629 @default.
• W1971319797 cites W2051948296 @default.
• W1971319797 cites W2075327558 @default.
• W1971319797 cites W2076834744 @default.
• W1971319797 cites W2079854145 @default.
• W1971319797 cites W2080270214 @default.
• W1971319797 cites W2083563185 @default.
• W1971319797 cites W2107792324 @default.
• W1971319797 cites W2109117841 @default.
• W1971319797 cites W2114331846 @default.
• W1971319797 cites W2114873132 @default.
• W1971319797 cites W2117761303 @default.
• W1971319797 cites W2136681370 @default.
• W1971319797 cites W2141636122 @default.
• W1971319797 cites W2149761960 @default.
• W1971319797 cites W2153536347 @default.
• W1971319797 cites W2164620775 @default.
• W1971319797 cites W2168637323 @default.
• W1971319797 cites W2344038510 @default.
• W1971319797 cites W4252368281 @default.
• W1971319797 doi "https://doi.org/10.1006/excr.2000.5093" @default.
• W1971319797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11161721" @default.
• W1971319797 hasPublicationYear "2001" @default.
• W1971319797 type Work @default.
• W1971319797 sameAs 1971319797 @default.
• W1971319797 citedByCount "19" @default.
• W1971319797 countsByYear W19713197972012 @default.
• W1971319797 countsByYear W19713197972013 @default.
• W1971319797 countsByYear W19713197972014 @default.
• W1971319797 countsByYear W19713197972015 @default.
• W1971319797 countsByYear W19713197972016 @default.
• W1971319797 countsByYear W19713197972018 @default.
• W1971319797 countsByYear W19713197972020 @default.
• W1971319797 countsByYear W19713197972023 @default.
• W1971319797 crossrefType "journal-article" @default.
• W1971319797 hasAuthorship W1971319797A5010562080 @default.
• W1971319797 hasAuthorship W1971319797A5020226093 @default.
• W1971319797 hasAuthorship W1971319797A5024602296 @default.
• W1971319797 hasAuthorship W1971319797A5030517507 @default.
• W1971319797 hasAuthorship W1971319797A5031319811 @default.
• W1971319797 hasAuthorship W1971319797A5061229411 @default.
• W1971319797 hasAuthorship W1971319797A5068778464 @default.
• W1971319797 hasAuthorship W1971319797A5080395353 @default.
• W1971319797 hasAuthorship W1971319797A5089517125 @default.
• W1971319797 hasConcept C104317684 @default.
• W1971319797 hasConcept C10858879 @default.
• W1971319797 hasConcept C112952253 @default.
• W1971319797 hasConcept C119062480 @default.
• W1971319797 hasConcept C142724271 @default.
• W1971319797 hasConcept C158617107 @default.
• W1971319797 hasConcept C167625842 @default.
• W1971319797 hasConcept C181199279 @default.
• W1971319797 hasConcept C183873130 @default.
• W1971319797 hasConcept C197534660 @default.
• W1971319797 hasConcept C204787440 @default.
• W1971319797 hasConcept C2776164576 @default.
• W1971319797 hasConcept C2780114586 @default.
• W1971319797 hasConcept C2780723820 @default.
• W1971319797 hasConcept C29512474 @default.
• W1971319797 hasConcept C3020332539 @default.
• W1971319797 hasConcept C49805395 @default.

• next