Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971319904> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W1971319904 endingPage "1200" @default.
- W1971319904 startingPage "1191" @default.
- W1971319904 abstract "A stable hybridoma secreting homogeneous antibody (immunoglobulin class IgG2a) has been prepared by fusion using cells of immunoglobulin non-secreter myeloma (P3X63Ag8.653) and spleen cells of mice which had previously been immunized with the NH2-terminal CNBr fragment of human fibrinogen, the so-called N-DSK [(A alpha 1-51, B beta 1-118, gamma 1-78)2]. In competitive ELISA or radioimmunoassay this antibody (MAb/1-8C6) cross-reacted with intact fibrinogen, N-DSK, a des fibrinopeptide A (des FPA) variant of N-DSK, the so-called (B)N-DSK, as well as the intact B beta chain (B beta 1-118) obtained from N-DSK. Also, and mot importantly, cross-reactivity was observed with fibrinogen-free ethanol extracts of plasma obtained from patients known to contain high levels of fibrinogen or fibrin degradation products. In vitro thrombin digestion of any of these competitors resulted in complete loss of cross-reactivity. MAb/1-8C6 did not react with the A alpha or gamma-chains of N-DSK, free fibrinopeptide B(FPB), free B beta 15-42, as well as equimolar mixtures of the latter two peptides. These results suggest that MAb/1-8C6 may be to an epitope in or around the thrombin-susceptible B beta 14 Arg-25 Gly bond. Furthermore, due to its reactivity with patient plasma extracts, this antibody may be useful in clinical investigations dealing with fibrino(geno)lysis." @default.
- W1971319904 created "2016-06-24" @default.
- W1971319904 creator A5012399299 @default.
- W1971319904 creator A5040625522 @default.
- W1971319904 creator A5067997545 @default.
- W1971319904 creator A5085603514 @default.
- W1971319904 creator A5085940021 @default.
- W1971319904 date "1983-11-01" @default.
- W1971319904 modified "2023-10-16" @default.
- W1971319904 title "A monoclonal antibody with ability to distinguish between NH2-terminal fragments derived from fibrinogen and fibrin" @default.
- W1971319904 cites W1521765521 @default.
- W1971319904 cites W1533436380 @default.
- W1971319904 cites W1539434116 @default.
- W1971319904 cites W1562590055 @default.
- W1971319904 cites W1601052229 @default.
- W1971319904 cites W1605067347 @default.
- W1971319904 cites W1972827382 @default.
- W1971319904 cites W2015051416 @default.
- W1971319904 cites W2025465724 @default.
- W1971319904 cites W2027141031 @default.
- W1971319904 cites W2030522563 @default.
- W1971319904 cites W2037081745 @default.
- W1971319904 cites W2041164401 @default.
- W1971319904 cites W2056499550 @default.
- W1971319904 cites W2059723436 @default.
- W1971319904 cites W2062476429 @default.
- W1971319904 cites W2077237408 @default.
- W1971319904 cites W2087737282 @default.
- W1971319904 cites W2089276240 @default.
- W1971319904 cites W2161983723 @default.
- W1971319904 cites W2395871307 @default.
- W1971319904 cites W2465708542 @default.
- W1971319904 doi "https://doi.org/10.1016/0161-5890(83)90142-6" @default.
- W1971319904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6656769" @default.
- W1971319904 hasPublicationYear "1983" @default.
- W1971319904 type Work @default.
- W1971319904 sameAs 1971319904 @default.
- W1971319904 citedByCount "57" @default.
- W1971319904 countsByYear W19713199042012 @default.
- W1971319904 countsByYear W19713199042013 @default.
- W1971319904 countsByYear W19713199042017 @default.
- W1971319904 countsByYear W19713199042019 @default.
- W1971319904 crossrefType "journal-article" @default.
- W1971319904 hasAuthorship W1971319904A5012399299 @default.
- W1971319904 hasAuthorship W1971319904A5040625522 @default.
- W1971319904 hasAuthorship W1971319904A5067997545 @default.
- W1971319904 hasAuthorship W1971319904A5085603514 @default.
- W1971319904 hasAuthorship W1971319904A5085940021 @default.
- W1971319904 hasConcept C153911025 @default.
- W1971319904 hasConcept C159654299 @default.
- W1971319904 hasConcept C176685330 @default.
- W1971319904 hasConcept C185592680 @default.
- W1971319904 hasConcept C195616568 @default.
- W1971319904 hasConcept C203014093 @default.
- W1971319904 hasConcept C2777292125 @default.
- W1971319904 hasConcept C2779036427 @default.
- W1971319904 hasConcept C54173615 @default.
- W1971319904 hasConcept C542903549 @default.
- W1971319904 hasConcept C55493867 @default.
- W1971319904 hasConcept C86803240 @default.
- W1971319904 hasConcept C89560881 @default.
- W1971319904 hasConceptScore W1971319904C153911025 @default.
- W1971319904 hasConceptScore W1971319904C159654299 @default.
- W1971319904 hasConceptScore W1971319904C176685330 @default.
- W1971319904 hasConceptScore W1971319904C185592680 @default.
- W1971319904 hasConceptScore W1971319904C195616568 @default.
- W1971319904 hasConceptScore W1971319904C203014093 @default.
- W1971319904 hasConceptScore W1971319904C2777292125 @default.
- W1971319904 hasConceptScore W1971319904C2779036427 @default.
- W1971319904 hasConceptScore W1971319904C54173615 @default.
- W1971319904 hasConceptScore W1971319904C542903549 @default.
- W1971319904 hasConceptScore W1971319904C55493867 @default.
- W1971319904 hasConceptScore W1971319904C86803240 @default.
- W1971319904 hasConceptScore W1971319904C89560881 @default.
- W1971319904 hasIssue "11" @default.
- W1971319904 hasLocation W19713199041 @default.
- W1971319904 hasLocation W19713199042 @default.
- W1971319904 hasOpenAccess W1971319904 @default.
- W1971319904 hasPrimaryLocation W19713199041 @default.
- W1971319904 hasRelatedWork W1972645132 @default.
- W1971319904 hasRelatedWork W1992169430 @default.
- W1971319904 hasRelatedWork W2028244478 @default.
- W1971319904 hasRelatedWork W2034887586 @default.
- W1971319904 hasRelatedWork W2055132998 @default.
- W1971319904 hasRelatedWork W2059693147 @default.
- W1971319904 hasRelatedWork W2061908783 @default.
- W1971319904 hasRelatedWork W2084926266 @default.
- W1971319904 hasRelatedWork W2468338477 @default.
- W1971319904 hasRelatedWork W2914507259 @default.
- W1971319904 hasVolume "20" @default.
- W1971319904 isParatext "false" @default.
- W1971319904 isRetracted "false" @default.
- W1971319904 magId "1971319904" @default.
- W1971319904 workType "article" @default.