FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971322894> ?p ?o ?g. }

• W1971322894 endingPage "10" @default.
• W1971322894 startingPage "1" @default.
• W1971322894 abstract "Peritoneal implantation of cancer cells, particularly postoperative seeding metastasis, frequently occurs in patients with primary tumors in the stomach, colon, liver, and ovary. Peritoneal carcinomatosis is associated with poor prognosis. In this work, we evaluated the prophylactic effect of intraperitoneal administration of selenium (Se), an essential trace element and a putative chemopreventive agent, on peritoneal implantation of cancer cells. Elemental Se nanoparticles were injected into the abdominal cavity of mice, into which highly malignant H22 hepatocarcinoma cells had previously been inoculated. Se concentrations in the cancer cells and tissues, as well as the efficacy of proliferation inhibition and safety, were evaluated. Se was mainly concentrated in cancer cells compared to Se retention in normal tissues, showing at least an order of magnitude difference between the drug target cells (the H22 cells) and the well-recognized toxicity target of Se (the liver). Such a favorable selective distribution resulted in strong proliferation suppression without perceived host toxicity. The mechanism of action of the Se nanoparticle-triggered cytotoxicity was associated with Se-mediated production of reactive oxygen species, which impaired the glutathione and thioredoxin systems. Our results suggest that intraperitoneal administration of Se is a safe and effective means of preventing growth of cancer cells in the peritoneal cavity for the above-mentioned high-risk populations." @default.
• W1971322894 created "2016-06-24" @default.
• W1971322894 creator A5029016218 @default.
• W1971322894 creator A5031310743 @default.
• W1971322894 creator A5038927917 @default.
• W1971322894 creator A5045937290 @default.
• W1971322894 creator A5078634339 @default.
• W1971322894 date "2014-07-01" @default.
• W1971322894 modified "2023-10-17" @default.
• W1971322894 title "Efficacy and safety of selenium nanoparticles administered intraperitoneally for the prevention of growth of cancer cells in the peritoneal cavity" @default.
• W1971322894 cites W1493015417 @default.
• W1971322894 cites W1581414347 @default.
• W1971322894 cites W1587890193 @default.
• W1971322894 cites W1803297532 @default.
• W1971322894 cites W1904486154 @default.
• W1971322894 cites W1963668163 @default.
• W1971322894 cites W1964440760 @default.
• W1971322894 cites W1964578158 @default.
• W1971322894 cites W1966203161 @default.
• W1971322894 cites W1967309052 @default.
• W1971322894 cites W1968871067 @default.
• W1971322894 cites W1984222809 @default.
• W1971322894 cites W1988392712 @default.
• W1971322894 cites W1995194620 @default.
• W1971322894 cites W1996694574 @default.
• W1971322894 cites W1999723018 @default.
• W1971322894 cites W2014823344 @default.
• W1971322894 cites W2015816281 @default.
• W1971322894 cites W2020420306 @default.
• W1971322894 cites W2021124426 @default.
• W1971322894 cites W2035743559 @default.
• W1971322894 cites W2040757416 @default.
• W1971322894 cites W2041312395 @default.
• W1971322894 cites W2045786144 @default.
• W1971322894 cites W2047520295 @default.
• W1971322894 cites W2049122462 @default.
• W1971322894 cites W2055785899 @default.
• W1971322894 cites W2065020384 @default.
• W1971322894 cites W2067686654 @default.
• W1971322894 cites W2068823574 @default.
• W1971322894 cites W2075734759 @default.
• W1971322894 cites W2082844053 @default.
• W1971322894 cites W2086961632 @default.
• W1971322894 cites W2095382420 @default.
• W1971322894 cites W2102056087 @default.
• W1971322894 cites W2112392983 @default.
• W1971322894 cites W2132322608 @default.
• W1971322894 cites W2136195082 @default.
• W1971322894 cites W2138115947 @default.
• W1971322894 cites W2165125887 @default.
• W1971322894 cites W2168433858 @default.
• W1971322894 cites W2197332903 @default.
• W1971322894 cites W3148354570 @default.
• W1971322894 doi "https://doi.org/10.1016/j.freeradbiomed.2014.04.003" @default.
• W1971322894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24727439" @default.
• W1971322894 hasPublicationYear "2014" @default.
• W1971322894 type Work @default.
• W1971322894 sameAs 1971322894 @default.
• W1971322894 citedByCount "56" @default.
• W1971322894 countsByYear W19713228942015 @default.
• W1971322894 countsByYear W19713228942016 @default.
• W1971322894 countsByYear W19713228942017 @default.
• W1971322894 countsByYear W19713228942018 @default.
• W1971322894 countsByYear W19713228942019 @default.
• W1971322894 countsByYear W19713228942020 @default.
• W1971322894 countsByYear W19713228942021 @default.
• W1971322894 countsByYear W19713228942022 @default.
• W1971322894 countsByYear W19713228942023 @default.
• W1971322894 crossrefType "journal-article" @default.
• W1971322894 hasAuthorship W1971322894A5029016218 @default.
• W1971322894 hasAuthorship W1971322894A5031310743 @default.
• W1971322894 hasAuthorship W1971322894A5038927917 @default.
• W1971322894 hasAuthorship W1971322894A5045937290 @default.
• W1971322894 hasAuthorship W1971322894A5078634339 @default.
• W1971322894 hasConcept C109316439 @default.
• W1971322894 hasConcept C121608353 @default.
• W1971322894 hasConcept C126322002 @default.
• W1971322894 hasConcept C141071460 @default.
• W1971322894 hasConcept C142724271 @default.
• W1971322894 hasConcept C185592680 @default.
• W1971322894 hasConcept C190283241 @default.
• W1971322894 hasConcept C202751555 @default.
• W1971322894 hasConcept C2776001837 @default.
• W1971322894 hasConcept C2778536324 @default.
• W1971322894 hasConcept C2779013556 @default.
• W1971322894 hasConcept C2780159080 @default.
• W1971322894 hasConcept C2780427987 @default.
• W1971322894 hasConcept C2780936613 @default.
• W1971322894 hasConcept C29730261 @default.
• W1971322894 hasConcept C48349386 @default.
• W1971322894 hasConcept C502942594 @default.
• W1971322894 hasConcept C55493867 @default.
• W1971322894 hasConcept C71924100 @default.
• W1971322894 hasConcept C96232424 @default.
• W1971322894 hasConcept C98274493 @default.
• W1971322894 hasConceptScore W1971322894C109316439 @default.
• W1971322894 hasConceptScore W1971322894C121608353 @default.
• W1971322894 hasConceptScore W1971322894C126322002 @default.

• next