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• W1971337497 abstract "The term “unstable angina” is generally used to describe different clinical conditions such as accelerated angina pectoris (increase of severity and frequency of known chronic angina), angina at rest, prolonged angina associated with ST segment and T wave changes, and new onset angina. The prognosis of patients with these clinical syndromes differs considerably, with the worst prognosis for those with prolonged angina or angina at rest. Therefore management of unstable angina, including the aggressiveness and timing of interventional techniques, initially depends on the clinical presentationi Unstable angina often progresses to myocardial infarction simultaneously with the progression of an underlying thrombotic process,, Both aspirin and heparin favorably influence the clinical course of patients with unstable angina. In three large trials,2W4 aspirin has been shown to reduce mortality and protect against myocardial infarction. Utility of heparin in unstable angina. Heparin (5000 U intravenous bolus, followed by 1000 U/hr) was more effective than aspirin in relieving acute ischemic symptoms in patients with unstable angina,57 6 and was significantly more effective than placebo in preventing acute myocardial infarction in such patients.5 In one study,2 which included only patients with unstable angina, heparin was administered as a continuous infusion, with the dose adjusted to maintain the coagulation time at 1.5 to 2 times control values. Excluding the aspirin-treated patients, myocardial infarction occurred in 1 of 118 heparin" @default.
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• W1971337497 date "1993-11-01" @default.
• W1971337497 modified "2023-09-27" @default.
• W1971337497 title "Therapeutic approach to unstable angina: Nitroglycerin, heparin, and combined therapy" @default.
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• W1971337497 doi "https://doi.org/10.1016/0002-8703(93)90688-6" @default.
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