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- W1971342662 abstract "Hypothermia is a well-known phenomenon which accompanies hypoglycemia in mammals. The present study was designed to test the hypothesis that nitric oxide (NO) plays a role in insulin-induced hypothermia. The body temperature (Tb) of awake, unrestrained rats was measured before and after systemic infusion of insulin (2U.kg−1.h−1), and intracerebroventricular administration of NG-nitro-L-arginine methyl ester (L-NAME, a nonselective NO synthase inhibitor, 200 μg/1 μl). We observed a significant reduction in body temperature after insulin infusion. L-NAME alone caused no significant change in body temperature. When the two treatments were combined, no change in Tb was observed. The data indicate that NO plays a key role in insulin-induced hypothermia." @default.
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- W1971342662 date "2001-01-01" @default.
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- W1971342662 title "Role of nitric oxide in insulin-induced hypothermia in rats" @default.
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- W1971342662 doi "https://doi.org/10.1016/s0361-9230(00)00423-8" @default.
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