FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971345995> ?p ?o ?g. }

• W1971345995 endingPage "402" @default.
• W1971345995 startingPage "396" @default.
• W1971345995 abstract "Telomerase and human papillomavirus (HPV) DNA were evaluated as potential markers of high-grade dysplasia in cervical cytological specimens. Cytology specimens were collected from patients at the time of colposcopic evaluation for management of a previous abnormal cytology test result. Telomerase activity was evaluated by the telomeric repeat amplification protocol (TRAP), and HPV DNA was detected by polymerase chain reaction with L1 consensus-sequence primers and filter hybridization genotyping. Telomerase was detected in 8 of 97 (8.2%) cases with normal cytology or benign cellular changes, in 7 of 98 (7.1%) cases of atypical squamous cells of undetermined significance (ASCUS), in 3 of 95 (3.2%) cases of low-grade squamous intraepithelial lesion (LSIL), and in 17 of 48 (35.4%) cases with high-grade squamous intraepithelial lesion (HSIL). High-risk HPVs were detected in 23 of 97 (23.7%) cases with normal/reactive cellular changes (RCC) cytology, in 28 of 98 (28.6%) cases of ASCUS, in 69 of 95 (72.6%) cases of LSIL, and in 35 of 48 (72.9%) cases of HSIL. Telomerase expression did not correlate with the detection of high-risk HPVs in any cytological diagnostic categories. Telomerase and HPV test results of cytological specimens were correlated with the histological diagnoses of concurrent cervical biopsy specimens. Telomerase showed a sensitivity of 29.9% and a specificity of 94.0% for biopsy-confirmed cervical intraepithelial neoplasia (CIN) II/III. In contrast, high-risk HPVs were detected in 70.1% of cases with underlying CIN II/III, with a specificity of 62.5%. A relatively high proportion of normal/RCC or ASCUS cases with telomerase-positive test results had underlying high-grade dysplasia on cervical biopsy. Thus, technical and practical limitations of the TRAP assay in cervical cytology specimens limit the practical application of telomerase as a diagnostic adjunct in cervical cytopathology." @default.
• W1971345995 created "2016-06-24" @default.
• W1971345995 creator A5039356590 @default.
• W1971345995 creator A5043824187 @default.
• W1971345995 creator A5044819876 @default.
• W1971345995 creator A5084710346 @default.
• W1971345995 creator A5086099448 @default.
• W1971345995 date "2004-04-01" @default.
• W1971345995 modified "2023-10-08" @default.
• W1971345995 title "Telomerase and human papillomavirus as diagnostic adjuncts for cervical dysplasia and carcinoma" @default.
• W1971345995 cites W129059858 @default.
• W1971345995 cites W1966743558 @default.
• W1971345995 cites W1968285394 @default.
• W1971345995 cites W1968586411 @default.
• W1971345995 cites W1972651021 @default.
• W1971345995 cites W1996439072 @default.
• W1971345995 cites W2000971601 @default.
• W1971345995 cites W2003626297 @default.
• W1971345995 cites W2004004266 @default.
• W1971345995 cites W2017352169 @default.
• W1971345995 cites W2026856852 @default.
• W1971345995 cites W2029735450 @default.
• W1971345995 cites W2032019822 @default.
• W1971345995 cites W2054178267 @default.
• W1971345995 cites W2079378073 @default.
• W1971345995 cites W2082283059 @default.
• W1971345995 cites W2093747557 @default.
• W1971345995 cites W2096478290 @default.
• W1971345995 cites W2101196984 @default.
• W1971345995 cites W2103287006 @default.
• W1971345995 cites W2114551234 @default.
• W1971345995 cites W2115346781 @default.
• W1971345995 cites W2133842226 @default.
• W1971345995 cites W2134462657 @default.
• W1971345995 cites W2140100637 @default.
• W1971345995 cites W2151164686 @default.
• W1971345995 cites W2153258255 @default.
• W1971345995 cites W2328181181 @default.
• W1971345995 cites W333391747 @default.
• W1971345995 cites W4237801062 @default.
• W1971345995 cites W4245463759 @default.
• W1971345995 cites W4251401925 @default.
• W1971345995 cites W4377854697 @default.
• W1971345995 doi "https://doi.org/10.1016/j.humpath.2003.08.028" @default.
• W1971345995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15116318" @default.
• W1971345995 hasPublicationYear "2004" @default.
• W1971345995 type Work @default.
• W1971345995 sameAs 1971345995 @default.
• W1971345995 citedByCount "27" @default.
• W1971345995 countsByYear W19713459952012 @default.
• W1971345995 countsByYear W19713459952014 @default.
• W1971345995 crossrefType "journal-article" @default.
• W1971345995 hasAuthorship W1971345995A5039356590 @default.
• W1971345995 hasAuthorship W1971345995A5043824187 @default.
• W1971345995 hasAuthorship W1971345995A5044819876 @default.
• W1971345995 hasAuthorship W1971345995A5084710346 @default.
• W1971345995 hasAuthorship W1971345995A5086099448 @default.
• W1971345995 hasConcept C104317684 @default.
• W1971345995 hasConcept C121608353 @default.
• W1971345995 hasConcept C126322002 @default.
• W1971345995 hasConcept C142724271 @default.
• W1971345995 hasConcept C174618031 @default.
• W1971345995 hasConcept C18823058 @default.
• W1971345995 hasConcept C2775894508 @default.
• W1971345995 hasConcept C2775924586 @default.
• W1971345995 hasConcept C2775934546 @default.
• W1971345995 hasConcept C2776235491 @default.
• W1971345995 hasConcept C2776511402 @default.
• W1971345995 hasConcept C2777083264 @default.
• W1971345995 hasConcept C2777343196 @default.
• W1971345995 hasConcept C2777546739 @default.
• W1971345995 hasConcept C2777661416 @default.
• W1971345995 hasConcept C2778220009 @default.
• W1971345995 hasConcept C2778654104 @default.
• W1971345995 hasConcept C2779534503 @default.
• W1971345995 hasConcept C55493867 @default.
• W1971345995 hasConcept C59822182 @default.
• W1971345995 hasConcept C71924100 @default.
• W1971345995 hasConcept C86803240 @default.
• W1971345995 hasConcept C94581717 @default.
• W1971345995 hasConceptScore W1971345995C104317684 @default.
• W1971345995 hasConceptScore W1971345995C121608353 @default.
• W1971345995 hasConceptScore W1971345995C126322002 @default.
• W1971345995 hasConceptScore W1971345995C142724271 @default.
• W1971345995 hasConceptScore W1971345995C174618031 @default.
• W1971345995 hasConceptScore W1971345995C18823058 @default.
• W1971345995 hasConceptScore W1971345995C2775894508 @default.
• W1971345995 hasConceptScore W1971345995C2775924586 @default.
• W1971345995 hasConceptScore W1971345995C2775934546 @default.
• W1971345995 hasConceptScore W1971345995C2776235491 @default.
• W1971345995 hasConceptScore W1971345995C2776511402 @default.
• W1971345995 hasConceptScore W1971345995C2777083264 @default.
• W1971345995 hasConceptScore W1971345995C2777343196 @default.
• W1971345995 hasConceptScore W1971345995C2777546739 @default.
• W1971345995 hasConceptScore W1971345995C2777661416 @default.
• W1971345995 hasConceptScore W1971345995C2778220009 @default.
• W1971345995 hasConceptScore W1971345995C2778654104 @default.
• W1971345995 hasConceptScore W1971345995C2779534503 @default.

• next