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• W1971350557 abstract "A patient with myeloma, hyperviscosity, and amyloidosis was shown to have an IgG3λ serum globulin and two different λ light chain fragments (Li I and Li II) in the urine. Both Li I and Li II were shown by antigenic and peptide analyses to be lacking a considerable portion, if not all of the Cλ domain. Partial sequence data demonstrated a blocked N-terminus and marked homology with a V region peptide (residues 67–90) of λ sub-group II. Li I had a molecular weight of 28,000 daltons and was reduced to 14,000 by mercaptoethanol. Li II had a molecular weight in the range of 12,000 daltons and exhibited marked insolubility at neutral pH. It is postulated that the relative insolubility of Li II at physiological pH might be related to certain of the clinical features of this case, particularly the amyloidosis." @default.
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• W1971350557 date "1981-04-01" @default.
• W1971350557 modified "2023-09-26" @default.
• W1971350557 title "Plasma cell myeloma, hyperviscosity and amyloidosis associated with a serum IgG3λ and urinary excretion of two fragments related to the variable portion of λ light chains" @default.
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• W1971350557 doi "https://doi.org/10.1016/0090-1229(81)90047-7" @default.
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