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• W1971383964 abstract "Silicon nanowires (SiNWs) offer promising inorganic nanostructures for biomedical application. Here, we report the development of a novel SiNW array designed for isolating primary CD4+ T lymphocytes from the heterogeneous mixture of cell populations. Our system employed the specific high-affinity binding features of streptavidin (STR)-functionalized SiNW with biotin-labeled CD4+ T lymphocytes. Fabricated SiNW arrays easily separated the CD4+ T lymphocytes from the mouse whole splenocytes with over ∼88% purity and demonstrated tight attachment to CD4+ T lymphocytes by scanning electron microscopy. Thus, our STR-SiNW arrays provide a potential tool for specific cell separation and further present a possibility to be applied to the other area of biomedical applications." @default.
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• W1971383964 date "2010-07-13" @default.
• W1971383964 modified "2023-10-17" @default.
• W1971383964 title "Novel Streptavidin-Functionalized Silicon Nanowire Arrays for CD4⁺ T Lymphocyte Separation" @default.
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• W1971383964 doi "https://doi.org/10.1021/nl100942p" @default.
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