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• W1971385195 abstract "In this study, the negative pressure values at which inertial cavitation consistently occurs in response to a single, two-cycle, focused ultrasound pulse were measured in several media relevant to cavitation-based ultrasound therapy. The pulse was focused into a chamber containing one of the media, which included liquids, tissue-mimicking materials, and ex vivo canine tissue. Focal waveforms were measured by two separate techniques using a fiber-optic hydrophone. Inertial cavitation was identified by high-speed photography in optically transparent media and an acoustic passive cavitation detector. The probability of cavitation (P(cav)) for a single pulse as a function of peak negative pressure (p(-)) followed a sigmoid curve, with the probability approaching one when the pressure amplitude was sufficient. The statistical threshold (defined as P(cav) = 0.5) was between p(-) = 26 and 30 MPa in all samples with high water content but varied between p(-) = 13.7 and >36 MPa in other media. A model for radial cavitation bubble dynamics was employed to evaluate the behavior of cavitation nuclei at these pressure levels. A single bubble nucleus with an inertial cavitation threshold of p(-) = 28.2 megapascals was estimated to have a 2.5 nm radius in distilled water. These data may be valuable for cavitation-based ultrasound therapy to predict the likelihood of cavitation at various pressure levels and dimensions of cavitation-induced lesions in tissue." @default.
• W1971385195 created "2016-06-24" @default.
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• W1971385195 date "2013-03-01" @default.
• W1971385195 modified "2023-09-30" @default.
• W1971385195 title "Probability of Cavitation for Single Ultrasound Pulses Applied to Tissues and Tissue-Mimicking Materials" @default.
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• W1971385195 doi "https://doi.org/10.1016/j.ultrasmedbio.2012.09.004" @default.
• W1971385195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3570716" @default.
• W1971385195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23380152" @default.
• W1971385195 hasPublicationYear "2013" @default.
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