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- W1971385655 abstract "Background Some patients with myelofibrosis (MF) progress to acute myeloid leukemia (AML). Current prognostic tools were not devised to assess risk of AML transformation. Methods Multivariate analysis in 649 patients followed for a median of 19 months (range, 1-180 months). Results We identified age > 60 (P = .004; hazard ratio [HR], 1.63), platelets <100 × 109/L (P < .001; HR, 1.62), bone marrow blast > 10% (P = .002; HR, 2.18), high-risk karyotype (P < .001; HR, 2.44), transfusion dependency (P < .001; HR, 2.64), performance status > 1 (P = .003; HR, 1.47), lactate dehydrogenase > 2000 U/L (P < .001; HR, 1.62), previous hydroxyurea (P < .001; HR, 1.69), and male sex (P = .005; HR, 1.41) as independent poor prognostic factors for survival. Using the same baseline variables we identified bone marrow blasts >10% and worst karyotype as independent risk factors for AML transformation. Patients with 1 or both of these risk factors (n = 80; 12%) had a median survival of 10 months and a 1-year AML transformation rate of 13% (2% if none of those factors, P = .001). Conclusion We have identified risk factors that predict high risk of transformation from MF to AML." @default.
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- W1971385655 date "2013-06-01" @default.
- W1971385655 modified "2023-09-27" @default.
- W1971385655 title "Prognostic Model to Identify Patients With Myelofibrosis at the Highest Risk of Transformation to Acute Myeloid Leukemia" @default.
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- W1971385655 doi "https://doi.org/10.1016/j.clml.2013.01.001" @default.
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