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• W1971408857 abstract "Botulinum neurotoxins (BoNTs) are the etiological agents responsible for botulism, a disease characterized by peripheral neuromuscular blockade and a characteristic flaccid paralysis of humans. The natural product toosendanin is a traditional Chinese medicine which has been reported to have anti-botulinum properties in animal models. To establish what chemical functionalities are necessary for the anti-botulinum properties found within toosendanin, a study was initiated with the goal of using function-oriented synthesis (FOS) as a strategy to begin to unravel toosendanin’s powerful anti-botulinum properties. From these studies a new synthetic strategy is put forth allowing access to a 4-acetoxy CD fragment analogue (14) of toosendanin, which was achieved from mesityl oxide and acetylacetone in 14 steps. Animal studies on this fragment are also reported." @default.
• W1971408857 created "2016-06-24" @default.
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• W1971408857 date "2009-02-01" @default.
• W1971408857 modified "2023-10-06" @default.
• W1971408857 title "Function-oriented synthesis applied to the anti-botulinum natural product toosendanin" @default.
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• W1971408857 doi "https://doi.org/10.1016/j.bmc.2008.12.042" @default.
• W1971408857 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2661763" @default.
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