Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971424145> ?p ?o ?g. }
- W1971424145 endingPage "13932" @default.
- W1971424145 startingPage "13924" @default.
- W1971424145 abstract "Decorin is a member of the widely expressed family of small leucine-rich proteoglycans. In addition to a primary role as a modulator of extracellular matrix protein fibrillogenesis, decorin can inhibit the cellular response to growth factors. Decorin expression is induced in endothelial cells during angiogenesis, but not when migration and proliferation are stimulated. Thus, decorin may support the formation of the fibrillar pericellular matrix that stabilizes the differentiated endothelial phenotype during the later stages of angiogenesis. Therefore, we tested whether constitutive decorin expression alone could modify endothelial cell migration and proliferation or affect pericellular matrix formation. To this end, replication-defective retroviral vectors were used to stably express bovine decorin, which was detected by Northern and Western blotting. The migration of endothelial cells that express decorin is significantly inhibited in both monolayer outgrowth and microchemotaxis chamber assays. The inhibition of cell migration by decorin was not accompanied by decreased proliferation. In addition, endothelial cells that express decorin assemble an extensive fibrillar fibronectin matrix more rapidly than control cells as assessed by immunocytochemical and fibronectin fibrillogenesis assays. These observations suggest that cell migration may be modulated by the influence of decorin on the assembly of the cell-associated extracellular matrix." @default.
- W1971424145 created "2016-06-24" @default.
- W1971424145 creator A5006131577 @default.
- W1971424145 creator A5035268339 @default.
- W1971424145 creator A5082088034 @default.
- W1971424145 creator A5091664271 @default.
- W1971424145 date "2000-05-01" @default.
- W1971424145 modified "2023-09-26" @default.
- W1971424145 title "Retrovirally Mediated Expression of Decorin by Macrovascular Endothelial Cells" @default.
- W1971424145 cites W103509626 @default.
- W1971424145 cites W125147743 @default.
- W1971424145 cites W1504348021 @default.
- W1971424145 cites W1505978562 @default.
- W1971424145 cites W1544527238 @default.
- W1971424145 cites W1547774078 @default.
- W1971424145 cites W1549463507 @default.
- W1971424145 cites W1572981633 @default.
- W1971424145 cites W1573262794 @default.
- W1971424145 cites W1853993502 @default.
- W1971424145 cites W189749484 @default.
- W1971424145 cites W1966039015 @default.
- W1971424145 cites W1980235826 @default.
- W1971424145 cites W1980534733 @default.
- W1971424145 cites W1987028756 @default.
- W1971424145 cites W1987664863 @default.
- W1971424145 cites W1992492704 @default.
- W1971424145 cites W1996764985 @default.
- W1971424145 cites W1999340769 @default.
- W1971424145 cites W2000904473 @default.
- W1971424145 cites W2002621910 @default.
- W1971424145 cites W2007834031 @default.
- W1971424145 cites W2012541010 @default.
- W1971424145 cites W2013381560 @default.
- W1971424145 cites W2023104790 @default.
- W1971424145 cites W2031354590 @default.
- W1971424145 cites W2034223183 @default.
- W1971424145 cites W2035819392 @default.
- W1971424145 cites W2036395308 @default.
- W1971424145 cites W2037341460 @default.
- W1971424145 cites W2039464229 @default.
- W1971424145 cites W2041294148 @default.
- W1971424145 cites W2041345827 @default.
- W1971424145 cites W2041813420 @default.
- W1971424145 cites W2042162619 @default.
- W1971424145 cites W2044859814 @default.
- W1971424145 cites W2053352199 @default.
- W1971424145 cites W2054171565 @default.
- W1971424145 cites W2054703329 @default.
- W1971424145 cites W2057094512 @default.
- W1971424145 cites W2058240687 @default.
- W1971424145 cites W2064735316 @default.
- W1971424145 cites W2070013317 @default.
- W1971424145 cites W2072336495 @default.
- W1971424145 cites W2073860634 @default.
- W1971424145 cites W2075073611 @default.
- W1971424145 cites W2090603283 @default.
- W1971424145 cites W2092889119 @default.
- W1971424145 cites W2100398824 @default.
- W1971424145 cites W2101896709 @default.
- W1971424145 cites W2127972419 @default.
- W1971424145 cites W2129591536 @default.
- W1971424145 cites W2131687641 @default.
- W1971424145 cites W2141877739 @default.
- W1971424145 cites W2142634963 @default.
- W1971424145 cites W2151621078 @default.
- W1971424145 cites W2153387848 @default.
- W1971424145 cites W2156606731 @default.
- W1971424145 cites W2159375050 @default.
- W1971424145 cites W2164152556 @default.
- W1971424145 cites W2165617997 @default.
- W1971424145 cites W2170900242 @default.
- W1971424145 cites W2298917175 @default.
- W1971424145 cites W2398248435 @default.
- W1971424145 cites W3191436203 @default.
- W1971424145 cites W4294216491 @default.
- W1971424145 cites W64210512 @default.
- W1971424145 doi "https://doi.org/10.1074/jbc.275.18.13924" @default.
- W1971424145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10788518" @default.
- W1971424145 hasPublicationYear "2000" @default.
- W1971424145 type Work @default.
- W1971424145 sameAs 1971424145 @default.
- W1971424145 citedByCount "73" @default.
- W1971424145 countsByYear W19714241452012 @default.
- W1971424145 countsByYear W19714241452013 @default.
- W1971424145 countsByYear W19714241452014 @default.
- W1971424145 countsByYear W19714241452015 @default.
- W1971424145 countsByYear W19714241452017 @default.
- W1971424145 countsByYear W19714241452018 @default.
- W1971424145 countsByYear W19714241452020 @default.
- W1971424145 countsByYear W19714241452021 @default.
- W1971424145 countsByYear W19714241452022 @default.
- W1971424145 crossrefType "journal-article" @default.
- W1971424145 hasAuthorship W1971424145A5006131577 @default.
- W1971424145 hasAuthorship W1971424145A5035268339 @default.
- W1971424145 hasAuthorship W1971424145A5082088034 @default.
- W1971424145 hasAuthorship W1971424145A5091664271 @default.
- W1971424145 hasBestOaLocation W19714241451 @default.
- W1971424145 hasConcept C153911025 @default.