FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1971455894> ?p ?o ?g. }

• W1971455894 endingPage "369" @default.
• W1971455894 startingPage "364" @default.
• W1971455894 abstract "The reduced folate carrier (RFCI) is essential for folate transport into cells. Low folate is an important cause of neural tube defects (NTDs), and a single-nucleotide polymorphism (H27R) (80G→A) in the RFCI gene has been reported to be a NTD risk factor. We investigated H27R and a 61bp tandem repeat polymorphism as potential risk factors for NTDs, using a large homogeneous Irish population by case/control comparison, log-linear analysis, and transmission disequilibrium testing. No association was found between NTDs and H27R in mothers [p = 0.23, odds ratio (OR) 0.87, 95% confidence interval (CI) 0.69–1.09], fathers (p = 0.11, OR 0.83, 95% CI 0.66–1.04), or cases (p = 0.36, OR 0.9, 95% CI 0.72–1.12) when compared to controls or through log-linear modeling for dominant or recessive effects or with the transmission disequilibrium test for preferential allele transmission. Using log-linear models, a significant protective case effect was seen for the 61 bp polymorphism (p = 0.0039, OR 0.21, 95% CI 0.05–0.85). When analyzed by genotype, individuals homozygous for a single copy of the 61 bp sequence were underrepresented in cases as compared to controls, although these results did not reach statistical significance (p = 0.081, OR 0.5, 95% CI 0.23–1.09, goodness of fit p = 0.42). We compared the frequencies of H27R and the 61 bp polymorphism in African-Americans and American-Caucasians. The frequencies of H27R polymorphism differed significantly between the two populations (p = 0.0001). This large study does not confirm previous reports that H27R is a risk factor for NTDs. The previously unstudied 61 bp tandem repeat, however, has a possible protective NTD effect in our Irish population. This requires confirmation in other studies." @default.
• W1971455894 created "2016-06-24" @default.
• W1971455894 creator A5008200942 @default.
• W1971455894 creator A5022379657 @default.
• W1971455894 creator A5037091799 @default.
• W1971455894 creator A5038433352 @default.
• W1971455894 creator A5041601792 @default.
• W1971455894 creator A5049362478 @default.
• W1971455894 creator A5059449911 @default.
• W1971455894 creator A5061331073 @default.
• W1971455894 creator A5067188351 @default.
• W1971455894 creator A5088033476 @default.
• W1971455894 date "2006-04-01" @default.
• W1971455894 modified "2023-10-07" @default.
• W1971455894 title "Reduced folate carrier polymorphisms and neural tube defect risk" @default.
• W1971455894 cites W1975066367 @default.
• W1971455894 cites W1998878958 @default.
• W1971455894 cites W2023452084 @default.
• W1971455894 cites W2031916109 @default.
• W1971455894 cites W2059926520 @default.
• W1971455894 cites W2070009272 @default.
• W1971455894 cites W2071269027 @default.
• W1971455894 cites W2101259585 @default.
• W1971455894 cites W2144062723 @default.
• W1971455894 cites W2148708125 @default.
• W1971455894 cites W2152664025 @default.
• W1971455894 cites W2161980441 @default.
• W1971455894 cites W2162530578 @default.
• W1971455894 cites W2171193990 @default.
• W1971455894 cites W2172013213 @default.
• W1971455894 cites W2325417132 @default.
• W1971455894 cites W4237533794 @default.
• W1971455894 doi "https://doi.org/10.1016/j.ymgme.2005.09.024" @default.
• W1971455894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16343969" @default.
• W1971455894 hasPublicationYear "2006" @default.
• W1971455894 type Work @default.
• W1971455894 sameAs 1971455894 @default.
• W1971455894 citedByCount "41" @default.
• W1971455894 countsByYear W19714558942012 @default.
• W1971455894 countsByYear W19714558942013 @default.
• W1971455894 countsByYear W19714558942014 @default.
• W1971455894 countsByYear W19714558942015 @default.
• W1971455894 countsByYear W19714558942016 @default.
• W1971455894 countsByYear W19714558942017 @default.
• W1971455894 countsByYear W19714558942021 @default.
• W1971455894 countsByYear W19714558942023 @default.
• W1971455894 crossrefType "journal-article" @default.
• W1971455894 hasAuthorship W1971455894A5008200942 @default.
• W1971455894 hasAuthorship W1971455894A5022379657 @default.
• W1971455894 hasAuthorship W1971455894A5037091799 @default.
• W1971455894 hasAuthorship W1971455894A5038433352 @default.
• W1971455894 hasAuthorship W1971455894A5041601792 @default.
• W1971455894 hasAuthorship W1971455894A5049362478 @default.
• W1971455894 hasAuthorship W1971455894A5059449911 @default.
• W1971455894 hasAuthorship W1971455894A5061331073 @default.
• W1971455894 hasAuthorship W1971455894A5067188351 @default.
• W1971455894 hasAuthorship W1971455894A5088033476 @default.
• W1971455894 hasConcept C104317684 @default.
• W1971455894 hasConcept C126322002 @default.
• W1971455894 hasConcept C135763542 @default.
• W1971455894 hasConcept C149737253 @default.
• W1971455894 hasConcept C153209595 @default.
• W1971455894 hasConcept C156957248 @default.
• W1971455894 hasConcept C196843134 @default.
• W1971455894 hasConcept C2776885448 @default.
• W1971455894 hasConcept C2780594696 @default.
• W1971455894 hasConcept C35605836 @default.
• W1971455894 hasConcept C44249647 @default.
• W1971455894 hasConcept C54355233 @default.
• W1971455894 hasConcept C65409693 @default.
• W1971455894 hasConcept C71924100 @default.
• W1971455894 hasConcept C86803240 @default.
• W1971455894 hasConcept C90924648 @default.
• W1971455894 hasConceptScore W1971455894C104317684 @default.
• W1971455894 hasConceptScore W1971455894C126322002 @default.
• W1971455894 hasConceptScore W1971455894C135763542 @default.
• W1971455894 hasConceptScore W1971455894C149737253 @default.
• W1971455894 hasConceptScore W1971455894C153209595 @default.
• W1971455894 hasConceptScore W1971455894C156957248 @default.
• W1971455894 hasConceptScore W1971455894C196843134 @default.
• W1971455894 hasConceptScore W1971455894C2776885448 @default.
• W1971455894 hasConceptScore W1971455894C2780594696 @default.
• W1971455894 hasConceptScore W1971455894C35605836 @default.
• W1971455894 hasConceptScore W1971455894C44249647 @default.
• W1971455894 hasConceptScore W1971455894C54355233 @default.
• W1971455894 hasConceptScore W1971455894C65409693 @default.
• W1971455894 hasConceptScore W1971455894C71924100 @default.
• W1971455894 hasConceptScore W1971455894C86803240 @default.
• W1971455894 hasConceptScore W1971455894C90924648 @default.
• W1971455894 hasFunder F4320306085 @default.
• W1971455894 hasFunder F4320312041 @default.
• W1971455894 hasFunder F4320332161 @default.
• W1971455894 hasFunder F4320337354 @default.
• W1971455894 hasFunder F4320337364 @default.
• W1971455894 hasIssue "4" @default.
• W1971455894 hasLocation W19714558941 @default.
• W1971455894 hasLocation W19714558942 @default.
• W1971455894 hasOpenAccess W1971455894 @default.

• next